ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 133-136.doi: 10.3969/j.issn.1674-3865.2018.02.013

• 临床研究 • 上一篇    下一篇

喜炎平注射液辅助改善肺炎支原体肺炎患儿免疫功能的研究

孙洪华   

  1. 122000 辽宁 朝阳，朝阳市第二医院儿科
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 作者简介:孙洪华（1969-），女，副主任医师。研究方向：新生儿疾病的诊断与治疗，E-mail:wanglijz@163.com

Assistance of Xiyanping injection in improving immunological function of children with mycoplasma pneumonia

SUN Honghua   

  1.  Department of Pediatrics, the Second Hospital of Chaoyang, Chaoyang 122000, China
  • Online:2018-04-25 Published:2018-11-19

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摘要：
目的
观察喜炎平注射液辅助阿奇霉素治疗对肺炎支原体肺炎（MPP）患儿免疫功能的影响。
方法
选取2014年1月至2016年10月朝阳市第二医院儿科门诊收治的MPP患儿60例，随机分为观察组和对照组各30例。对照组应用静脉滴注阿奇霉素治疗，观察组在对照组治疗基础上加用喜炎平注射液静脉滴注。7 d为1个疗程，连续治疗2个疗程。观察两组临床疗效、细胞免疫功能（CD4+、CD8+水平）及体液免疫功能（IgA、IgG、IgM水平）。
结果
观察组患儿总有效率为90.0%（27/30），显著高于对照组66.7%（20/30），差异有统计学意义（P<0.05）。治疗后两组CD4+水平以及CD4+/CD8+值均显著高于治疗前，CD8+水平显著低于治疗前，差异有统计学意义（P<0.05）；治疗后观察组CD4+水平以及CD4+/CD8+值显著高于对照组，而CD8+水平显著低于对照组，差异有统计学意义（P<0.05）。治疗后两组患儿血清IgM、IgA水平显著低于治疗前，而IgG水平高于治疗前，差异有统计学意义（P<0.05）。治疗后观察组血清IgM、IgA、IgG水平均显著低于对照组，差异有统计学意义（P<0.05）。
结论
相较于单独应用阿奇霉素，喜炎平可辅助性地从细胞免疫和体液免疫两方面增强MPP患儿的机体免疫功能，提高临床疗效。

关键词: 支原体肺炎, 喜炎平注射液, 阿奇霉素, 细胞免疫, 体液免疫, 儿童

Abstract:
objective
To investigate the effects of combined treatment with azithromycin and Xiyanping injection on immunological function of children with mycoplasma pneumonia.
Methods
Sixty children with mycoplasma pneumonia were included and equally randomized into treatment group and control group(30 in each group). Children in the control group received intravenous administration of azithromycin, and those in the treatment group received intravenous administration of azithromycin combined with Xiyanping injection. The treatment lasted for 2 courses, with 7 days in one course. The treatment efficacy was observed. The CD4+ and CD8+ levels as well as IgA, IgG and IgM levels were also observed.
Results
The total effective rate in the treatment group was significantly higher than that in the control group(90% vs 67%, P<0.05). Serum CD4+ level and the ratio of CD4+/CD8+ were significantly increased, while serum CD8+ level was significantly decreased in both groups after treatment compared with before treatment (P<0.05). Serum CD4+ level and the ratio of CD4+/CD8+ were significantly increased, while serum CD8+ level was significantly decreased in the treatment group compared with the control group(P<0.05). After treatment, serum levels of IgM and IgA were significantly decreased, while the serum level of IgG was significantly increased in both groups (P<0.05). Serum levels of IgM, IgA and IgG were significantly decreased in the treatment group compared with the control group(P<0.05).
Conclusion
Xiyanping injection can assist azithromycin in improving immunological function of children with mycoplasma pneumonia, thereby enhancing the treatment efficacy.

Key words: Mycoplasma pneumonia, Xiyanping injection, Azithromycin, Cell immunity, Humoral immunity, Children