ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 159-162.doi: 10.3969/j.issn.1674-3865.2018.02.021

• 临床研究 • 上一篇    下一篇

玉屏风散联合丙酸氟替卡松治疗肺脾气虚型小儿咳嗽变异性哮喘疗效观察

张小林，吴慧静，邱美霞，赵腾飞，刘克伟   

  1. 510470 广州，广州市白云区中医医院儿科(张小林，吴慧静，邱美霞)；510800 广州，广州市花都区妇幼保健院儿科(赵腾飞，刘克伟)
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 通讯作者: 吴慧静，E-mail：1023599179@qq.com
  • 作者简介:张小林(1978-)，男，副主任医师。研究方向：中西医结合治疗小儿呼吸系统疾病

Clinical observation on Yupingfeng powder combined with fluticasone propionate aerosol for cough variant asthma of pulmonosplenic-qi deficiency type in children

ZHANG Xiaolin，WU Huijing，QIU Meixia，ZHAO Tengfei，LIU Kewei   

  1.  Guangzhou Baiyun District Hospital of Traditional Chinese Medicine, Guangzhou 510470, China
  • Online:2018-04-25 Published:2018-11-19

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摘要：
目的
观察玉屏风散颗粒联合丙酸氟替卡松吸入治疗小儿咳嗽变异性哮喘（CVA）肺脾气虚证的临床效果。
方法
选择2016年4月至2017年2月广州市白云区中医医院及广州市花都区妇幼保健院收治的CVA患儿90例为研究对象，随机分为观察组和对照组各45例。观察组脱落3例，最终42例；对照组脱落5例，最终40例。对照组单用丙酸氟替卡松气雾剂呼吸道吸入，观察组在对照组治疗基础上联合玉屏风颗粒口服，两组疗程为12周，观察两组临床疗效、咳嗽缓解和消失时间、不良反应；治疗完成后4周，随访比较两组临床疗效。
结果
治疗完成时，观察组总有效率为92.9%（39/42），高于对照组77.5%（31/40），差异有统计学意义（P<0.05）；观察组咳嗽缓解及消失时间显著短于对照组，差异有统计学意义（P<0.05）；治疗完成后4周，观察组总有效率88.1%（37/42），仍然高于对照组65.0%（26/40），差异有统计学意义（P<0.05），与治疗完成时相比，差异无统计学意义（P>0.05）。治疗期间未发生明显不良反应。
结论
玉屏风散颗粒联合丙酸氟替卡松气雾剂在改善肺脾气虚型CVA患儿的症状方面优于单用丙酸氟替卡松气雾剂。

关键词: 咳嗽变异性哮喘, 玉屏风散, 丙酸氟替卡松, 肺脾气虚, 儿童

Abstract:
objective
To observe the clinical effect of Yupingfeng powder combined with fluticasone propionate aerosol for cough variant asthma of pulmonosplenic-qi deficiency type in children.
Methods
From April 2016 to February 2017, 90 cases of CVA children admitted to Baiyun District Hospital of Traditional Chinese Medicine and Huadu District Maternal and Child Health Hospital in Guangzhou were selected as the research subjects, and they were randomly divided into two groups:45 cases in the observation group and 45 in the control group. Three cases fell off in the observation group, with 42 cases included in the end; in the control group 5 cases fell off and finally 40 cases were included. The observation group was given oral Yupingfeng powder combined with fluticasone propionate aerosol and the control group was given fluticasone propionate aerosol. The two groups were treated for 12 weeks. The clinical efficacy, cough relief and disappearance time and adverse reactions of the two groups were observed. Four weeks after completion of treatment，the clinical effects of the two groups were compared by follow-up.
Results
After treatment, the total effective rate of the observation group(92.86%,39/42) was higher than that of the control group(77.50%,31/40), and the difference was statistically significant(P<0.05). The cough relief and disappearance time in the observation group was significantly shorter than that in the control group, and the difference was statistically significant(P<0.05). Four weeks after completion of treatment，the total effective rate of observation group(88.10%,37/42) was still higher than that of the control group(65%,26/40), and the difference was statistically significant(P<0.05), but the difference was not statistically significant(P>0.05) compared with that at the end of treatment. No obvious adverse reactions occurred during the treatment.
Conclusion
Yupingfeng powder granules combined with fluticasone propionate aerosols are superior to fluticasone alone in improving the symptoms of children with CVA of pulmonosplenic-qi deficiency type.

Key words: Cough variant asthma, Yupingfeng powder, Fluticasone propionate aerosol, Pulmonosplenic-qi deficiency type, Children