ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (3): 200-202.doi: 10.3969/j.issn.1674-3865.2018.03.005

• 临床研究 • 上一篇    下一篇

呼出气一氧化氮测定在儿童咳嗽变异性哮喘中的诊断价值

苏艳琦，王丹，闫昕婕，范雪   

  1. 113008 辽宁 抚顺，抚顺矿务局总医院儿科
  • 出版日期:2018-06-25 发布日期:2018-11-19
  • 通讯作者: 苏艳琦，E-mail：fsyq@sina.com
  • 作者简介:苏艳琦（1968-），女，医学硕士，主任医师。研究方向：小儿呼吸系统疾病的诊治及小儿急救

Diagnostic value of determination of exhaled nitric oxide in children with cough variant asthma

SU Yanqi, WANG Dan, YAN Xinjie, FAN Xue   

  1.  Department of Padiatrics，Fushun Mining Administration General Hospital，Fushun 113008，China
  • Online:2018-06-25 Published:2018-11-19

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146

摘要：
目的
测定咳嗽变异性哮喘（CVA）患儿呼出气一氧化氮（FeNO）的变化，探讨FeNO在儿童CVA中的诊断价值。
方法
2015年1月至2016年10月抚顺矿务局总医院儿科收治CVA患儿30例，为CVA组/同期选取感染后咳嗽（PIC）患儿30例，为PIC组。分别测定两组患儿FeNO和IgE水平。
结果
两组FeNO、IgE水平均升高，CVA组FeNO水平为（33.23±16.29）×10-9mol/L，显著高于PIC组（19.30±9.87）×10-9mol/L，差异有统计学意义（P<0.01）；IgE水平两组比较差异无统计学意义（P>0.05）。
结论
在儿童慢性咳嗽的诊断中，FeNO可作为辅助诊断CVA的一种检测方法。

关键词: 咳嗽变异性哮喘, 呼出气一氧化氮, IgE, 儿童

Abstract:
Objective
To determine the changes of exhaled nitric oxide(FeNO) in children with cough variant asthma(CVA), and to explore the diagnostic value of FeNO in children's CVA.
Methods
Thirty cases of children with CVA admitted to Pediatric Department of Fushun Mining Administration General Hospital from January 2015 to October 2016 were set as CVA group; 30 cases of children with cough(PIC) after infection were selected during the same period and they were set as PIC group. The levels of FeNO and IgE were measured separately in two groups.
Results
The levels of FeNO and IgE were increased in both groups, The levels in CVA group were (33.23±16.29)×10-9mol/L, significantly higher than those of the PIC group［(19.30±9.87)×10-9mol/L］, the difference being statistically significant(P<0.01). There was no significant difference in IgE levels between the two groups(P>0.05).
Conclusion
In the diagnosis of chronic cough in children, FeNO can be used as a diagnostic method for the diagnosis of CVA.

Key words: Cough variant asthma, Exhaled nitric oxide, IgE, Children