关键词: 高热惊厥, 网络药理学, 钩藤, 分子机制

Abstract: Objective To explore the molecular mechanism of Uncaria rhynchophylla in the treatment of febrile convulsion by using network pharmacology.Methods The main active components of Uncaria rhynchophylla were obtained through TCMSP database and literature mining, and the targets of active components of Uncaria rhynchophylla were predicted and screened by Perl language analysis, OMIM and Gene Cards database. Cytoscape software was used to construct component-target-pathway-disease network. A protein interaction network was mapped using the String database. With the help of Bioconductor-cluster Profiler database, GO analysis and KEGG pathway analysis were carried out on targets.Results Totally 27 active components of Uncaria rhynchophylla were screened, mainly alkaloids, terpenes and flavonoinds, and alkaloids accounted for the most part, and 46 targets were involved. Uncaria rhynchophylla could play a role in treating FC by regulating AGE-RAGE, IL-17, HIF-1,TNF,PI3K-Akt and other signaling pathways.
Conclusion The active components, such as alkaloids, terpenes and flavonoids, in Uncaria rhynchophylla may be the material basis for treating FC, and their mechanism of action involves signal pathways such as AGE-RAGE,IL-17,HIF-1,TNF,PI3K-Akt.Uncaria rhynchophylla is effective in treating FC by regulating inflammatory response, cell apoptosis and the adaptability of neurons to hypoxia.

Key words: Febrile convulsion, Network pharmacology, Uncaria rhynchophylla, Molecular mechanisms