ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (4): 337-340.doi: 10.3969/j.issn.1674-3865.2020.04.017

• 临床研究 • 上一篇    下一篇

支气管舒张试验在5岁以下儿童哮喘中的应用

邓胜蓝，姜新萍，罗付华，刘毅然，梁婷，李海磐   

  1. 417000 湖南 娄底，娄底市中心医院儿科23病室
  • 出版日期:2020-08-25 发布日期:2021-05-17
  • 通讯作者: 姜新萍，E-mail：546981329@qq.com
  • 作者简介:邓胜蓝（1986-），女，医学硕士，主治医师。研究方向：儿童呼吸与免疫疾病的诊治
  • 基金资助:
    娄底市应用技术研究与开发项目［（2018）50］

Bronchodilation test in asthmatic children under 5 years old

  • Online:2020-08-25 Published:2021-05-17

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摘要： 目的 探讨潮气呼吸法支气管舒张试验在5岁以下哮喘患儿中的临床应用。
方法 将近2年我院诊治的190例哮喘患儿作为研究对象，据年龄分3组，6～12个月为Ⅰ组（26例）、1～<3岁为Ⅱ组（72例）、3～5岁为Ⅲ组（92例）。据支气管阻塞程度分轻、中、重度组，以0.5%沙丁胺醇作为支气管舒张药物，用潮气呼吸肺功能分析各组吸药前后肺功能指标变化。
结果 1）190例哮喘患儿及其中Ⅱ组患儿吸药前后达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)比较差异有统计学意义(P＜0.05)。（2）中、重度阻塞患儿吸药前后TPTEF/TE、VPEF/VE比较差异均有统计学意义(P＜0.05)。（3）3组不同阻塞程度患儿支气管舒张试验阳性率比较差异有统计学意义（P<0.05）。
结论 潮气呼吸法支气管舒张试验可以反映5岁以下哮喘患儿气道阻塞的可逆性特征。潮气呼吸法支气管舒张试验在阻塞程度较重的哮喘患儿中诊断价值较大。

关键词: 支气管哮喘, 潮气呼吸肺功能, 支气管舒张试验, 儿童

Abstract: Objective To study clinical application of bronchodilation test of tidal breathing lung function test in asthmatic children under 5 years old.
Methods A total of 190 asthmatic children who came to our hospital for diagnosis and treatment between Jan. 1,2018 and Oct. 31,2019 were recruited as research subjects. They were divided into three groups according to their ages: group Ⅰ( 6 months to 1 year old,26 cases) , group Ⅱ(1 to 3 years old,72 cases), group Ⅲ(3 to 5 years old,92 cases). According to the degree of bronchial obstruction, the patients were divided into light, medium and severe groups. All received 0.5% salbutamol. Tidal breathing flowvolume loop and parameters obtained before and after aerosol inhalation were evaluated.〖JP〗
Results (1)There was significant difference in TPTEF/TE and VPEF/VE in 190 asthmatic children and the children in groups Ⅱ before and after inhaling the drug(P<0.05).(2)There was significant difference in TPTEF/TE and VPEF/VE in medium and severe groups before and after inhaling the drug(P<0.05).(3)There was significant difference in the positive rate of bronchodilation test among the three groups with different degrees of obstruction(P<0.05).
Conclusion Bronchodilation test of tidal breathing lung function test can reflect the reversibility of airway obstruction in asthmatic children under 5 years old. Bronchodilation test of tidal breathing lung function test is of great value in the diagnosis of asthmatic children with severe obstruction.

Key words: Bronchial asthma, Tidal breathing lung function, Bronchodilation test, Children