ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (6): 496-499.doi: 10.3969/j.issn.1674-3865.2021.06.010

• 临床研究 • 上一篇    下一篇

儿童川崎病并发冠状动脉损害患儿C反应蛋白、血小板参数及羧化不全骨钙素的水平及其意义

李淑娟, 梁宏, 陈晓轶   

  1. 450018 郑州，郑州大学附属儿童医院，河南省儿童医院，郑州儿童医院普通内科

  • 收稿日期:2021-10-15 出版日期:2021-12-25 上线日期:2021-12-25
  • 通讯作者: 李淑娟，E-mail：lisj_1982@163.com
  • 基金资助:
    河南省医学科技攻关项目（2018020695）

Level and significance of C-reactive protein, platelet parameters and undercarboxylated osteocalcin in children with Kawasaki disease complicated with coronary artery lesions

LI Shujuan, LIANG Hong, CHEN Xiaoyi   

  1. Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018,China

  • Received:2021-10-15 Published:2021-12-25 Online:2021-12-25
  • Contact: LI Shujuan，E-mail：lisj_1982@163.com

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摘要： 目的 探讨川崎病并发冠状动脉损害(CALs)患儿血清C反应蛋白(CRP)、血小板计数(PLT)及羧化不全骨钙素(ucOC)水平及意义。方法 选取2017年9月至2019年9月在我院治疗的川崎病患儿72例为观察组,同期选取健康体检儿童70例作为对照组。检测血清CRP、PLT及ucOC水平,采用超声心动图检查川崎病患儿CALs发生情况。结果 观察组CRP和PLT明显高于对照组,ucOC明显低于对照组,差异有统计学意义(P<0.05);经超声心动图检查,有25例患儿伴有CALs;观察组伴CALs患儿CRP明显高于不伴CALs患儿,ucOC水平明显低于不伴CALs患儿,差异有统计学意义(P<0.05);观察组伴和不伴CALs患儿PLT比较差异无统计学意义(P>0.05);CRP、ucOC诊断川崎病患儿伴CALs的ROC曲线下面积分别为0.701和0.651(P<0.05),截断值分别为74.69 mg/L和12.36μg/L,灵敏性分别为48.00%和52.00%,特异性分别为87.23%和89.36%。结论 川崎病并发CALs患儿CRP、PLT及ucOC水平升高,其中CRP和ucOC在诊断川崎病并发CALs中有一定应用价值。 

关键词: 川崎病, 冠状动脉损害, C反应蛋白, 血小板计数, 羧化不全骨钙素, 儿童

Abstract: Objective To investigate the serum C-reactive protein(CRP) level, platelet count(PLT) and undercarboxylated osteocalcin(ucOC) levels in children with Kawasaki disease complicated with coronary artery lesions(CALs) and its significance.Methods Totally 72 cases(observation group) of children with Kawasaki disease treated in our hospital from September 2017 to September 2019 were selected, and 70 healthy children receiving physical examination during the same period were selected as the control group. The serum CRP, PLT and ucOC levels were detected, and the occurrence of CALs in children with Kawasaki disease was examined by echocardiography.Results The CRP and PLT in the observation group were significantly higher than those in the control group(P<0.05), while ucOC was significantly lower than those in the control group(P<0.05). There were 25 children with CALs by echocardiography. In the observation group, CRP in children with CALs was significantly higher than that in children without CALs(P<0.05), while ucOC was significantly lower(P<0.05). There was no significant difference in PLT between children with and those without CALs in observation group(P>0.05). The area under ROC curve of CRP and ucOC in diagnosing Kawasaki disease with CALs was 0.701 and 0.651(P<0.05).Cut-off values were 74.69 mg/L and 12.36 g/L, the sensitivity was 48.00% and 52.00%, and specificity was 87.23% and 89.36%, respectively.Conclusion CRP, PLT and ucOC levels are increased in children with Kawasaki disease complicated with CALs, among which CRP and ucOC has certain application value in diagnosing Kawasaki disease complicated with CALs.

Key words: Kawasaki , disease, Coronary artery lesion, C-reactive protein, Platelet count, Undercarboxylated osteocalcin, Children