ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (1): 16-20.doi: 10.3969/j.issn.1674-3865.2022.01.005

• 临床论著 • 上一篇    下一篇

益气缓哮汤治疗儿童支气管哮喘慢性持续期的临床研究

李东楠, 王海, 邢鑫鑫, 刘博男, 王圣楠   

  1. 150040 哈尔滨，黑龙江中医药大学第一临床医学院2019级中医儿科学专业研究生（李东楠，王圣楠）；150040 哈尔滨，黑龙江中医药大学附属第一医院儿科（王海，邢鑫鑫，刘博男）

  • 收稿日期:2021-03-08 出版日期:2022-02-25 上线日期:2022-02-25
  • 通讯作者: 王海，E-mail：wanghai576@163.com
  • 基金资助:
    黑龙江中医药大学新药研究基金（2019XY05）

Clinical study on treating bronchial asthma at chronic persistent phase in children with Yiqi Huanxiao decoction

LI Dongnan, WANG Hai, XING Xinxin, LIU Bonan, WANG Shengnan   

  1. The First Clinical Medical College,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040，China

  • Received:2021-03-08 Published:2022-02-25 Online:2022-02-25
  • Contact: WANG Hai，E-mail：wanghai576@163.com

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摘要： 目的 通过观察益气缓哮汤治疗儿童支气管哮喘慢性持续期的临床疗效，探讨其有效性。方法 选择2018年1月至2020年1月我院收治的支气管哮喘慢性持续期气虚痰结证患儿120例，随机分为观察组和对照组各60例。对照组给予雾化吸入布地奈德联合孟鲁司特钠咀嚼片治疗。观察组给予益气缓哮汤治疗。记录并比较两组患儿治疗前后哮喘症状积分、哮喘控制测试问卷(C-ACT)评分、肺功能指标、血清免疫球蛋白水平、肺部高分辨率CT马赛克征评分，并进行统计。结果 观察组、对照组各脱落7例。观察组总有效率为94.34%(50/53),高于对照组81.14%(43/53),差异有统计学意义(P<0.05)。两组患儿哮喘症状积分、C-ACT评分、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)指标、血清免疫球蛋白IgA、IgG、IgM水平、肺部高分辨率CT马赛克征评分均较治疗前明显降低，且观察组明显低于对照组，差异有统计学意义(P<0.05)。结论 益气缓哮汤治疗儿童支气管哮喘慢性持续期优于传统西药治疗，具有临床推广价值。

关键词: 支气管哮喘, 慢性持续期, 气虚痰结证, 儿童

Abstract: Objective To observe the clinical effect of Yiqi Huanxiao decoction on bronchial asthma at chronic persistent phase in children and to explore its effectiveness.Methods Totally 120 children with chronic persistent Qi-deficiency and phlegm-stasis syndrome of bronchial asthma were randomly divided into experimental group and control group,with 60 in each group.The control group was treated with nebulized budesonide combined with montelukast sodium chewable tablets.The experimental group was treated with Yiqi Huanxiao decoction.Record and compare asthma symptom score,C-ACT score,lung function index,serum immunoglobulin level,lung HRCT mosaic sign score,and carry out the statistical analysis.Results There were 7 cases in each group which were lost to follow.The total effective rate in the experimental group was 94.34%(50/53),higher than that in the control group (81.14%,43/53),and the difference was of statistical significance (P<0.05).The asthma symptom score,C-ACT score,FEV1/FVC index,serum immunoglobulin IgA,IgG and IgM level,and lung HRCT mosaic score were significantly lower than those before treatment,and the experimental group was significantly lower than the control group,the difference being statistically significant (P<0.05).Conclusion The treatment with Yiqi Huanxiao decoction for bronchial asthma at chronic persistent phase in children is superior to traditional western medicine,which has clinical popularization value.

Key words:

Bronchial asthma, Chronic persistent phase, Qi-deficiency and phlegm-stasis syndrome, Children