ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (4): 339-343.doi: 10.3969/j.issn.1674-3865.2023.04.014

• 中医应用研究 • 上一篇    下一篇

三种不同身高预测方法在健脾滋阴方治疗痰湿壅滞型性早熟女童中的比较研究

芦小叶, 赵鋆, 金莺, 杨楚文, 宋勤丽, 周芳源   

  1. 201203 上海，上海中医药大学附属曙光医院儿科（芦小叶，赵鋆，杨楚文，宋勤丽，周芳源）；311100 杭州，浙江中医药大学附属第一医院（浙江省中医院）儿童重症康复科（金莺）
  • 收稿日期:2023-05-24 出版日期:2023-08-25 上线日期:2023-08-25
  • 通讯作者: 赵鋆，E-mail：annezhao@sina.com
  • 基金资助:
    上海市进一步加快中医药传承创新发展三年行动计划（2021~2023年）资助（ZY〔2021-2023〕-0206-02）；上海市科学技术委员会科研计划项目（18401904700）；上海市科学技术委员会科研计划项目（17401970900）

A comparative study of three different height prediction methods in girls with precocious puberty of phlegm-dampness obstruction type treated by Jianpi Ziyin prescription

LU Xiaoye, ZHAO Jun, JIN Ying, YANG Chuwen, SONG Qinli, ZHOU Fangyuan   

  1. Pediatric Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

  • Received:2023-05-24 Published:2023-08-25 Online:2023-08-25
  • Contact: ZHAO Jun，E-mail：annezhao@sina.com

PDF (PC)

78

摘要： 目的 比较3种身高预测方法(生长曲线法、Bayley-Pinneau法、新的方法)对健脾滋阴方治疗后的性早熟女童的预测成人身高(PAH)的预测价值。方法 选取2005年1月1日至2016年6月30日就诊于上海中医药大学附属曙光医院儿科内分泌专科门诊痰湿壅滞型性早熟女童40例。就诊时平均年龄(7.20±0.85)岁，治疗全过程仅使用健脾滋阴方加减，疗程2年以上，进行终身高随访。采用Greulich-Pyle图谱法交叉、盲法读片，并用3种方法PAH,与患儿已达到的终身高进行比较。结果 40例患儿的终身高为(164.46±4.66)cm。治疗前、治疗1年、停药时生长曲线法的PAH分别为(156.35±5.24)cm、(157.11±5.42)cm、(159.74±4.37)cm; Bayley-Pinneau法PAH分别为(161.84±7.40)cm、(163.18±7.46)cm,(165.83±5.95)cm;新的方法PAH分别为(154.64±7.24)cm、(157.90±7.29)cm、(161.49±5.77)cm。各组治疗前与停药时PAH比较，差异有统计学意义(P<0.05)。每个治疗节点PAH分别与终身高比较，治疗大于1年的Bayley-Pinneau法PAH,差异无统计学意义(P>0.05)。生长曲线法、Bayley-Pinneau法、新的方法停药时PAH与终身高均呈正相关(r=0.70,0.75,0.71),终身高与PAH差值分别为(4.72±3.48)cm,(-1.37±3.99)cm、(2.97±4.11)cm, 95%可信区间分别为3.61～5.84、-2.64～-0.90、1.66～4.29。结论 Bayley-Pinneau法更适合预测健脾滋阴方治疗痰湿壅滞型性早熟女童的成人身高。

关键词: 性早熟, 健脾滋阴方, 女童, 痰湿壅滞, 预测成人身高

Abstract: Objective To compare three different height prediction methods ［growth curve method, Bayley-Pinneau (B-P) method and new method］ in girls with precocious puberty of phlegm-dampness obstruction type after the treatment with Jianpi Ziyin prescription, and analyze their value in predicting adult height (PAH). Methods Forty precocious puberty girls with phlegm-dampness obstruction were chosen, who were treated in Pediatric Department of shanghai University of Traditional Chinese Medicine from Jan. 1,2005 to June 30,2016. Their mean age on visiting the hospital was 7.20±0.85 years old. Only Jianpi Ziyin prescription was used during the whole process of treatment. The treatment lasted for 2 years, and the girls' final height was followed up.  Greulich-Pyle atlas method and estimated PAH method were used, and the three methods were used to predict adult height， which was compared with the final height. Results The final height of the 40 girls was (164.46±4.66)cm. The PAH before treatment, at 1 year of treatment and when the drug was stopped was (156.35±5.24)cm,(157.11±5.42)cm and (159.74±4.37)cm by growth curve method; it was (161.84±7.40)cm， (163.18±7.46)cm and (165.83±5.95)cm by B-P method; it was (154.64±7.24)cm，(157.90±7.29)cm and (161.49±5.77)cm by new method.The comparison of PAH before treatment and when the drug was stopped among the groups showed statistical difference(P<0.05). Comparing the PAH at each treatment stage with the final height, there was no statistical difference in PAH by B-P method at more than one year of treatment (P>0.05). The PAH when the drug was stopped by growth curve method. B-P method and new method was all positively correlated with the final height(r=0.70,0.75,0.71),and the difference between final height and PAH was (4.72±3.48)cm, (-1.37±3.99)cm and (2.97±4.11)cm, with the 95%CI being 3.61 to 5.84, -2.64 to -0.90 and 1.66 to 4.29.Conclusion The Bayley-Pinneau method is more suitable for predicting adult height of girls with precocious puberty of phlegm-dampness obstruction type treated by Jianpi Ziyin prescription.

Key words:

Precocious puberty, Jianpi Ziyin prescription, Girl, Phlegm-dampness obstruction, Predicting adult height