ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (5): 388-392.doi: 10.3969/j.issn.1674-3865.2023.05.005

• 儿童抽动障碍康复专栏 • 上一篇    下一篇

祛风止动贴治疗中度抽动障碍的随机对照临床研究

高原, 吴敏, 姜科宇, 张欣, 赵欣   

  1. 200072 上海，上海交通大学医学院附属新华医院中医科

  • 收稿日期:2023-09-10 出版日期:2023-10-25 上线日期:2023-10-25
  • 通讯作者: 赵欣，E-mail：zhao.xin88@163.com

A randomized controlled clinical study on the treatment of moderate tic disorder with Qufeng Zhidong plaster

GAO Yuan, WU Min, JIANG Keyu, ZHANG Xin, ZHAO Xin   

  1. Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200072，China
  • Received:2023-09-10 Published:2023-10-25 Online:2023-10-25
  • Contact: ZHANG Xin，E-mail：zhao.xin88@163.com

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摘要： 目的评价祛风止动贴治疗中度抽动障碍的临床疗效。方法2021年1月至2022年12月在上海交通大学医学院附属新华医院抽动障碍专科门诊及中医儿科门诊评估为中度抽动障碍的患儿140例，随机分为观察组和对照组各70例。所有患者予祛风止动方基础治疗，在此基础上观察组加贴祛风止动贴，对照组加贴空白模拟贴。治疗3个月后评价两组患者的临床疗效及中医证候评分的变化。结果观察组脱落剔除5例，对照组脱落剔除8例。治疗12周不良反应发生率观察组和对照组比较差异无统计学意义(P>005)。治疗12周末观察组临床总有效率为9538%（62/65），高于对照组8387%（52/62），差异有统计学意义(P<005)。两种治疗方法均对抽动障碍患儿耶鲁综合抽动严重程度量表评分有所改善，祛风止动贴+祛风止动方中药饮片治疗优于模拟贴+祛风止动方中药饮片治疗，差异有统计学意义（P<005）。治疗12周末观察组疗效总评评分低于对照组，疗效指数评分高于对照组，差异均有统计学意义(P<005)。治疗8周和12周末观察组中医证候评分低于对照组，差异有统计学意义(P<005)。结论祛风止动贴联合中药治疗中度抽动障碍疗效较佳，可显著改善患者的临床症状和中医证候。

关键词: 抽动障碍, 祛风止动贴, 临床疗效评价

Abstract: Objective To evaluate the clinical effect of Qufeng Zhidong plaster in the treatment of moderate tic disorder. Methods From January 2021 to December 2022, 140 children were evaluated as moderate tic disorder in the tic disorder specialist clinic and the traditional Chinese medicine pediatric clinic of Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and were randomly divided into the observation group and the control group, with 70 cases in each group. All patients were treated with Qufeng Zhidong formula. On this basis, Qufeng Zhidong plaster was used in the observation group and blank simulated plaster was used in the control group. After 3 months of treatment, the clinical efficacy and TCM syndrome score of the two groups were evaluated. Results Five cases were removed from the observation group and 8 cases were removed from the control group. At 12 weeks after treatment, there was no statistical difference in the incidence of adverse reactions between the observation group and control group (P>0.05), and the total clinical effective rate of the observation group was 95.38% (62/65), which was higher than that of the control group (83.87%,52/62), and the difference was statistically significant (P<0.05). The YGTSS score of children with tic disorder was improved by both treatment methods. The treatment of Qufeng Zhidong plaster plus Qufeng Zhidong formula was better than that of simulated plaster plus Qufeng Zhidong formula, and the difference was statistically significant (P<0.05). After 12 weeks of treatment, the total efficacy score of the observation group was lower than that of the control group, and the efficacy index score was higher than that of the control group, the difference being with statistical significance (P<0.05). The TCM syndrome score of the observation group was lower than that of the control group at 8 weeks and 12 weeks after treatment, and the difference was statistically significant(P<0.05). Conclusion Qufeng Zhidong plaster combined with Chinese medicine is effective in the treatment of moderate tic disorder, and can significantly improve the clinical symptoms and TCM syndromes of patients.

Key words:

Tic disorder, Qufeng Zhidong plaster, Clinical efficacy evaluation