ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (6): 526-529.doi: 10.3969/j.issn.1674-3865.2024.06.014

• 临床研究 • 上一篇    下一篇

单纯性肥胖儿童血清维生素D表达水平及其与肥胖相关性

戚玲, 钱红萍, 应波   

  1. 311500 杭州，浙江省桐庐县妇幼保健院儿科
  • 收稿日期:2024-04-09 修回日期:2024-05-17 出版日期:2024-12-25 上线日期:2024-12-25
  • 通讯作者: 戚玲，E-mail：385126917@qq.com

Expression level of serum vitamin D in children with simple obesity and its correlation with obesity

QI Ling，QIAN Hongping，YING Bo   

  1. Tonglu County Maternal and Child Health Hospital,Hangzhou 311500，China
  • Received:2024-04-09 Revised:2024-05-17 Published:2024-12-25 Online:2024-12-25
  • Contact: QI Ling，E-mail：385126917@qq.com

PDF (PC)

119

摘要： 目的：探讨单纯性肥胖儿童及正常体质量儿童血清维生素D（25-(OH)D3）表达水平差异及肥胖程度与血清25-(OH)D3的相关性。方法：选取2020年12月至2022年12月于桐庐县妇幼保健院就诊的单纯性肥胖儿童80例为肥胖组，同期选取就诊的正常体质量儿童80例为对照组。肥胖组中轻度肥胖25例，中度45例，重度10例。分别记录两组儿童的性别、年龄、身高、体质量、体质量指数(BMI)以及测定血清25-(OH)D3水平。对两组儿童基线资料进行对比分析，比较轻、中、重度肥胖儿童血清25-(OH)D3表达水平差异，采用Pearson相关分析比较两组儿童血清25-(OH)D3水平与肥胖程度（Z-BMI）相关性。结果：肥胖组体质量及BMI分别为（59.01±13.63）kg、25.72±3.24，明显高于对照组（41.37±12.10）kg、19.26±2.42，差异均有统计学意义（P<0.001）。肥胖组儿童25-(OH)D3为（19.95±7.10）μg/L，明显低于对照组（29.33±6.39）μg/L，差异有统计学意义（P<0.001）。轻、中、重度肥胖儿童血清25-(OH)D3分别为（25.25±5.51），（19.78±8.05），（14.46±6.37）μg/L，3组间比较差异有统计学意义（P<0.001）。进一步比较轻、中、重度肥胖儿童男女血清25-(OH)D3水平比较差异无统计学意义（P>0.05）。Pearson相关分析表明儿童血清25-(OH)D3与肥胖程度（Z-BMI）呈负相关（r=-0.473，P<0.05）。结论：单纯性肥胖儿童血清25-(OH)D3水平明显低于正常体质量儿童，儿童肥胖程度与血清25-(OH)D3水平呈负相关，肥胖儿童应注意补充维生素D。

关键词: 单纯性肥胖, 维生素D, 25羟维生素D3, 儿童

Abstract: Objective：To investigate the difference in serum vitamin D (25-hydroxyvitamin D3) level between simple obese children and normal-weight children and the correlation between obesity and serum 25-(OH)D3.Methods：We selected 80 cases of children with simple obesity as the obesity group,who visited our hospital between December 2020 and December 2022.Additionally,we included 80 cases of normal-weight children without obesity as the control group,who visited our hospital during the same period.The obesity group included 25 cases of mild obesity,45 cases of moderate obesity,and 10 cases of severe obesity.Both groups were recorded for gender,age,height,weight and body mass index(BMI),and their serum 25-(OH)D3 levels were determined.The baseline data of two groups of children were compared and analyzed.The difference in serum 25-(OH)D3 expression levels was compared among the children with mild obesity,moderate obesity and severe obesity.Pearson′s correlation analysis was used to analyze the correlation between serum 25-(OH)D3 levels and Z-BMI in the children of the two groups.Results：The children in the obesity group had an average weight of (59.01±13.63)kg and an average BMI of 25.72±3.24.In comparison,the control group had an average weight of (41.37±12.10)kg and an average BMI of 19.26±2.42.The difference between the two groups was statistically significant (P<0.001).The average serum 25-(OH)D3 of children in the obesity group was (19.95±7.10) μg/L,which was significantly lower than the average serum 25-(OH)D3 of children in the control group,which was (29.33±6.39) μg/L (P<0.001).Among the obese children,those in the mild,moderate,and severe groups had serum 25-(OH)D3 levels of (25.25±5.51)μg/L,(19.78±8.05)μg/L,and (14.46±6.37)μg/L,respectively,and the difference among the three groups was statistically significant (P<0.001).No gender difference was found in serum 25-(OH)D3 levels among children in the three groups (P>0.05).Pearson′s correlation analysis revealed a negative correlation between serum 25-(OH)D3 levels and Z-BMI in children(r=-0.473,P<0.05).Conclusion：Serum 25-(OH)D3 levels are significantly lower in children with simple obesity than in normal-weight children,and there is a negative correlation between the degree of obesity and serum 25-(OH)D3 levels in children.Obese children should take vitamin D supplements.

Key words: Simple obesity, Vitamin D, 25-hydroxyvitamin D3, Child