ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2011, Vol. 3 ›› Issue (1): 2-4.doi: 10.3969/j.issn.1674-3865.2011.01.002

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小儿急性非细菌感染性腹泻病126例随机对照临床研究

许华，刘华，曾永梅，丘小汕，肖达民，莫清萍，潘瑞芳，石艳红，胡小英，许双虹   

  1. 510405 广州，广州中医药大学第一附属医院儿科（许华，刘华，胡小英，许双虹）；510120 广州，广州市儿童医院消化内科（曾永梅，潘瑞芳）；510080 广州，中山大学附属第一医院儿科（丘小汕，莫清萍）；510130 广州，广州市中医院儿科（肖达民，石艳红）
  • 收稿日期:2009-12-10 出版日期:2011-02-25 上线日期:2011-02-25
  • 通讯作者: 许华,E-mail：xuhua212@126.com
  • 作者简介:许华（1965-），女，医学博士，教授、主任医师，博士研究生导师。研究方向：小儿脾胃病及小儿血证的诊断与治疗,E-mail：xuhua212@126.com。
  • 基金资助:
    国家“十一五”科技支撑计划中医治疗常见病项目（2007BAI20B024）

Clinical randomized controlled study of 126 cases of acute non bacterial infectious diarrhea  in children

XU Hua,LIU Hua，ZENG Yong mei   

  1. Department of Pediatrics，the First Affiliated Hospital of Guangzhou University of TCM，Guangzhou 510405，China
  • Received:2009-12-10 Published:2011-02-25 Online:2011-02-25

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摘要： 目的：对中医治疗小儿泄泻进行随机对照临床研究，以客观规范地评价运脾化湿法治疗小儿急性非细菌感染性腹泻病的临床疗效。方法：采用前瞻性、多中心的随机对照临床研究方法，将126例急性非细菌性腹泻病患儿分为试验1组、试验2组、对照组，分配比例为1∶1∶1，分别采用中药汤剂、中药汤剂+推拿、蒙脱石散（思密达）进行治疗，观察临床症状改善情况及治疗效果。结果：（1）试验1组、试验2组、对照组的显效率分别为51.16%、65.71%、34.15%，组间比较差异有统计学意义(P＜0.05)；（2）试验1组、试验2组、对照组治疗2 d成形便分别为11例、7例、1例，组间差异均有统计学意义(P＜0.05)；（3）试验1组、试验2组、对照组的止泻时间分别为（4.30±2.39）d、（4.31±2.79）d、（5.49±2.69）d，差异无统计学意义(P＞0.05)。结论：中药及中药+推拿治疗小儿泄泻在显效率及改善患儿大便性状方面优于思密达。

关键词: 泄泻；腹泻/中医药疗法, 推拿；儿童

Abstract: Objective：A randomized controlled clinical study of Chinese medicine in infantile diarrhea treatment was conducted to evaluate objectively and in a standard way the effect of main therapeutic method of Activating Spleen and Dissipating Dampness on infantile acute nonbacterial infectious diarrhea.Methods：The clinical study was designed as a prospective, multi-center,randomized,control trial.Totally 126 infants with acute nonbacterial diarrhea were allocated into test group A,test group B and the control group in proportion of 1∶1∶1 with central randomization system.The treatment of Chinese herb,Chinese herb combined with massage and Montmorillonite powder was applied to the three groups respectively.Results：Significant effect rate in test group A,test group B and the control group was 51.16%，65.17%，34.15%，respectively,and there was a significant difference(P＜0.05) in the three groups.(2)On the second day of treatment,there was a significant difference on changing characters of stool in the three groups(P＜0.05).(3)The antidiarrheal time of test group A,test group B and the control group was （4.30±2.39）days，（4.31±2.79）days，（5.49±2.69）days，which showed no significant difference by statistical analysis(P＞0.05).Conclusions：Chinese medicine group and Chinese herb combined with massage are superior to Montmorillonite powder on changing characters of stool.

Key words: Diarrhea, Diarrhea/TCM therapy, Massage, Children