ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 627-629.doi: 10.3969/j.issn.1674-3865.2015.06.034

• 临床研究 • 上一篇    下一篇

痰热清注射液联合阿奇霉素治疗儿童肺炎支原体肺炎疗效观察

彭秋香   

  1. 415900湖南 常德,湖南省汉寿县人民医院儿科
  • 出版日期:2015-12-25 上线日期:2018-11-19
  • 作者简介:彭秋香(1974-),女,副主任医师。研究方向：小儿临床疾病的诊断与治疗，Email：zcl040338@126.com

Clinical observation on the effect of Tanreqing injection combined with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia

PENG Qiuxiang   

  1. Department of Pediatrics, Hanshou People's Hospital, Changde 415900, China.
  • Published:2015-12-25 Online:2018-11-19

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摘要：
目的:观察痰热清注射液联合阿奇霉素治疗儿童肺炎支原体肺炎的临床疗效。
方法:2012-01/2013-12湖南省汉寿县人民医院儿科收治儿童肺炎支原体肺炎患儿126例，随机分为两组。对照组60例给予阿奇霉素序贯疗法,按10 mg/(kg·d),每日1次,前1~3 d静脉滴注,后改为口服,疗程7 d；观察组66例在对照组治疗的基础上加用痰热清注射液0.3~0.5 mL/(kg·d),每日1次静脉滴注；疗程7 d,如病情需要,可间隔3 d进行第2个疗程。疗程结束后观察两组疗效、退热及咳嗽消失时间、肺部啰音消失及肺部X线片改善时间,出院前对两组药物不良反应进行分析。
结果:与对照组比较,观察组退热和咳嗽消失时间,肺部啰音消失时间,肺部X线片改善时间明显优于对照组,两组比较差异有统计学意义(P＜0.05或P＜0.01)。观察组总有效率为96.9%(64/66),优于对照组85.0%(51/60)。两组药物不良反应均较轻微,差异无统计学意义(P＞0.05)。
结论:痰热清注射液联合阿奇霉素治疗儿童肺炎支原体肺炎临床症状缓解快,疗效肯定,无药物不良反应发生,较单用阿奇霉素具有一定的优势,值得推广应用。

关键词: 肺炎, 肺炎, 支原体, 致病力, 痰热清, 治疗应用, 阿奇霉素, 治疗应用, 儿童

Abstract:
Objective：To observe the effect of Tanreqing injection combined with azithromycin in treatment of children with Mycoplasma pneumoniae pneumonia (MPP).
Methods：Totally 126 cases of children with Mycoplasma pneumoniae pneumonia were randomly divided into two groups. Control group (n=60)was given azithromycin sequential therapy, 10 mg/(kg·d), once a day, through intravenous drip for the first 3 days,and later it was changed to oral taking and treatment lasted for 7 d; observation group (66 cases), in addition to the above treatment,was treated with Tanreqing injection at 0.3 to 0.5 mL/(kg·d), once daily by intravenous infusion; treatment lasted for 7 d, and the second course might be performed 3days after the first course if needed. After the treatment, observe the curative effect of the two groups, fever and cough disappearing time,and pulmonary rales disappearing and lung Xray improvement time. Before discharge the adverse drugs reaction of two groups was analyzed.
Results：The fever and cough disappearing time, pulmonary rales disappearance time, and lung Xray improvement time were significantly better in the observation group than in the control group,and the difference between the two groups had statistical significance (P＜0.05 or P＜0.01). The total effective rate in the observation group was 96.9% (64/66), which was better than that of the control group, 85% (51/60). The adverse reactions of the two groups were mild, and the difference was not statistically significant (P＞0.05) between the two groups.
Conclusion：Tanreqing injection combined with azithromycin can alleviate clinical symptoms quickly in children with Mycoplasma pneumoniae pneumonia. Curative effect is significant,and no adverse drug reactions occur. Compared with single use of azithromycin it has certain advantages, and is worthy of popularization and application.

Key words: Pneumonia, Pneumonia, Mycoplasma, pathogenicity, Tanreqing injection, therapeutic use, Azithromycin, therapeutic use, Children