ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 569-571.doi: 10.3969/j.issn.1674-3865.2016.06.005

• 临床研究 • 上一篇    下一篇

新生儿重度缺氧缺血性脑病预后因素临床分析

黄维清，彭小明   

  1. 410007 长沙，湖南省儿童医院新生儿科
  • 出版日期:2016-12-25 上线日期:2018-11-19
  • 通讯作者: 彭小明，E-mail：pxmprf@163.com
  • 作者简介:黄维清(1979-)，医学硕士，主治医师。研究方向：新生儿疾病的诊治

Clinical analysis of the prognostic factors of neonatal severe hypoxic ischemic encephalopathy

HUANG Weiqing，PENG Xiaoming   

  1. Neonatal Department，Children's Hospital of Hunan Province，Changsha 410007，China
  • Published:2016-12-25 Online:2018-11-19

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摘要： 目的：探讨新生儿重度缺氧缺血性脑病的预后因素。
方法：2011年1月至2014年12月湖南省儿童医院新生儿科收治住院的重度新生儿缺氧缺血性脑病患儿131例，对其预后影响因素进行相关和回归分析。
结果：单因素分析显示5 min Apgar评分、惊厥、昏迷、pH值、剩余碱值、脏器损伤是影响重度新生儿缺氧缺血性脑病预后的危险因素；多因素Logistic分析结果表明，5 min Apgar评分<3分(OR＝4.256，95%CI 1.501～15.432)、剩余碱≤-10 mmol/L(OR＝37.208，95%CI 6.053～42.105)是影响重度新生儿缺氧缺血性脑病预后的独立性危险因素(P<0.05)，入院日龄<72 h(OR＝0.098，95%CI 0.032～0.367)是重度新生儿缺氧缺血性脑病保护因素。
结论：影响重度新生儿缺氧缺血性脑病预后的因素很多，及时发现这些因素，是预防重度新生儿缺氧缺血性脑病的关键所在，临床医师应该引起重视和早期干预。

关键词: 缺氧缺血性脑病, 重度, 预后因素, 婴儿, 新生

Abstract: Objective:To investigate the prognostic factors of neonatal severe hypoxic ischemic encephalopathy.
Methods:A total of 131 cases of HIE neonates were admitted and treated in Children's Hospital of Hunan Province from Jan. 2011 to Dec. 2014，and a regression analysis was make on the prognostic factors.
Results：Single factor analysis showed that 5 min Apgar score，convulsions，coma，pH value，BE value and organ damage were the prognostic risk factors of severe HIE in neonates. Multi-factor Logistic analysis showed that the 5 min Apgar score less than 3(OR＝4.256，95%CL 1.501~15.432）and BE value no more than -10 mmol/L（OR＝37.208，95%CL 6.053~42.105） were the independent prognostic rick factors of severe HIE (P<0.05)；the hospital stay shorter than 72 h(OR＝0.098，95%CL 0.032~0.367) was the protective factor of severe HIE in neonates.
Conclusion：There are many factors that influence the prognosis of severe HIE in neonates. It is the key to the preventing severe neonatal HIE to find these factors as early as possible，so clinical physicians should pay attention to it and perform early intervention.

Key words: Hypoxic-ischemic encephalopathy, Severe, Prognostic factors, Infants, newborn