ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (1): 6-8.doi: 10.3969/j.issn.1674-3865.2018.01.002

• 实验论著 • 上一篇    下一篇

壮药防病香囊对气虚小鼠呼吸道sIgA及IgG分泌的影响

王力宁,张毅贤,邓普元,李洁,周志宁   

  1. 530023 南宁，广西中医药大学第一附属医院儿科
  • 收稿日期:2017-05-31 出版日期:2018-02-25 上线日期:2018-02-25
  • 通讯作者: 王力宁，E-mail：wln21@126.com
  • 作者简介:王力宁（1956-），女，教授。研究方向：哮喘与肺系疾病的防治
  • 基金资助:
    国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015040）；广西名中医民族医传承工作室建设项目(桂卫中〔2013〕10号)

Effects of Anti-disease Sachet(a type of Zhuang medicine) on the secretion of respiratory sIgA and IgG in Qi-deficiency mice

WANG Lining，ZHANG Yixian，DENG Puyuan，LI Jie，ZHOU Zhining   

  1. First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine，Nanning 530023，China
  • Received:2017-05-31 Published:2018-02-25 Online:2018-02-25
  • Contact: WANG Lining，E-mail：wln21@126.com

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摘要： 目的:观察壮药防病香囊对气虚小鼠局部免疫功能的影响，探讨其预防反复呼吸道感染的部分疗效机制。方法:选用SPF级昆明种小白鼠24只，体质量18～22 g，雌雄兼用，随机分为空白组、模型组、香模组、香囊组，每组6只。先予壮药防病香囊连续干预4周，并于第4周开始造气虚模型，造模成功后予ELISA法检测肺泡灌洗液sIgA及IgG的浓度。结果:模型组与香模组小鼠肺泡灌洗液中sIgA比较差异无统计学意义（P>0.05）；香囊组小鼠肺泡灌洗液中sIgA显著高于空白组和模型组，差异有统计学意义（P<0.05）。4组小鼠肺泡灌洗液中IgG比较差异无统计学意义（P>0.05）。结论:壮药防病香囊有提高呼吸道免疫功能的作用，可用于预防小儿反复呼吸道感染。

关键词: 气虚;壮药防病香囊;sIgA, IgG;小鼠

Abstract: Objective:To study the effect of Anti-disease Sachet(a type of Zhuang medicine) on local immune function in Qi-deficiency mice, and to explore its mechanism in prevention and treatment of recurrent respiratory tract infection.Methods:A total of 24 SPF mice of Kunming species were chosen(male and female), whose body mass was 18-22 g. They were randomly divided into four groups: blank group, model group, incense module group and sachet group, with 6 mice in each group. They were intervened by Anti-disease Sachet for 4 weeks, and at the fourth week, Qi-deficiency model was established; after that, ELISA was used to determine the concentration of sIgA and IgG in the alveolar lavage fluid.Results:There was no statistical difference in sIgA in alveolar fluid between model group and sachet group(P>0.05). The sIgA in alveolar fluid of mice was significantly higher in sachet group than in blank group and model group, and there was statistical difference(P<0.05). There was no statistical difference in IgG in alveolar fluid of mice among the four groups(P>0.05).Conclusion:Anti-disease Sachet(a type of Zhuang medicine) is effective in improving respiratory immune function, so it can be used to prevent recurrent respiratory tract infection in children.

Key words: Qi-deficiency;Anti-disease Sachet(a type of zhuang medicine);sIgA, IgG;Mice