ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (1): 44-48.doi: 10.3969/j.issn.1674-3865.2020.01.012

• 临床研究 • 上一篇    下一篇

肾炎止血汤治疗儿童孤立性血尿型紫癜性肾炎疗效观察

李勇军，王海   

  1. 150040 哈尔滨，黑龙江中医药大学2018级中医儿科学专业研究生（李勇军）；黑龙江中医药大学附属第一医院儿科二科（王海）
  • 收稿日期:2019-10-15 出版日期:2020-02-25 上线日期:2020-02-25
  • 通讯作者: 王海，E-mail：782955547＠qq.com
  • 作者简介:李勇军（1997-），男，黑龙江中医药大学2018级硕士研究生在读。研究方向：中医药治疗儿童泌尿系统疾病

Clinical observation of the effect of Shenyan Zhixue decoction on children with Henoch Schonlein purpura nephritis of isolated hematuriatype

LI Yongjun,WANG Hai   

  • Received:2019-10-15 Published:2020-02-25 Online:2020-02-25
  • Contact: WANG Hai，E-mail：782955547＠qq.com

PDF (PC)

50

摘要： 目的 观察国医大师张琪教授经验方肾炎止血汤治疗儿童孤立性血尿型紫癜性肾炎的临床疗效。 方法 选取2017年6月至2019年7月黑龙江中医药大学附属第一医院儿科门诊收治的孤立性血尿型紫癜性肾炎患儿104例，随机分为观察组和对照组各52例。观察组口服肾炎止血汤，对照组口服血尿胶囊，疗程均为3个月。对比两组患儿于治疗前、治疗2周、1个月、2个月、3个月后尿常规红细胞计数和中医证候变化情况。 结果 观察组脱落4例，对照组脱落10例。治疗2周、1个月、2个月、3个月观察组有效率分别为73.0%（38/52）、82.7%(43/52)、86.0%(43/50)、89.6%(43/48)，高于对照组59.6%(31/52)、60.0%(30/50)、61.7%(29/47)、64.3%(27/42),差异有统计学意义（P<0.05）；两组患儿尿常规红细胞计数和手足心热、盗汗等中医证候积分均较治疗前明显降低，且观察组明显低于对照组，差异有统计学意义（P<0.05）。 结论 肾炎止血汤可以明显降低孤立性血尿型紫癜性肾炎患儿尿中红细胞计数，疗效显著，且未出现明显药物不良反应。

关键词: 孤立性血尿, 紫癜性肾炎, 阴虚火旺, 肾炎止血汤, 儿童

Abstract: Objective To observe the clinical effect of TCM master ZHANG Qi′s proven prescription Shenyan Zhixue decoction on the children with Henoch Schonlein purpura nephritis of isolated hematuria type. Methods A total of 104 patients with Henoch Schonlein purpura nephritis of isolated hematuria type were divided into test group and control group,with 52 patients in each group.The test group took Shenyan Zhixue decoction orally,while the control group took hematuresis capsule orally.Both groups were treated for three months as a course.The RBC count in routine urine and TCM syndromes were observed at 2 weeks,1 month,2 months and 3 months after taking medicine. Results There were 4 cases of dropping in the test group and 10 cases in the control group.After 2 weeks,1 month,2 months and 3 months,the total effective rate in the test group (73.0%,82.%,86.0% and 89.6%) was significantly higher than that in the control group(59.6%,60 0%,61.7% and 64.3%) (P<0.05).The RBC count in urine and the scores of TCM syndrome such as feverish palms and soles and night sweating in the two groups were significantly lower than those before treatment,and in the test group they were significantly lower than in the control group,the difference being statistically significant (P<0.05). Conclusion Shenyan Zhixue decoction can reduce the RBC count in urine of children with Henoch Schonlein purpura nephritis of isolated hematuria type.The effect is significant and there isn′t obvious adverse drug reactions.

Key words: Isolated hematuria, Henoch Schonlein purpura nephritis, Hyperactivity of fire due to yin deficiency, Shenyan Zhixue decoction, Children