ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (1): 17-.

• 临床研究 • 上一篇    下一篇

孤独症谱系障碍儿童营养情况与血清矿物质含量分析

李娜，李晓锋，王阳，韦焕苹，李鸥，赵旭生   

  1. 110032 沈阳，沈阳市儿童医院，沈阳市儿童神经康复重点实验室（李娜，李晓锋，王阳，韦焕苹，李鸥）；110179 沈阳，沈阳市医药质谱技术重点实验室（赵旭生）
  • 出版日期:2021-02-25 发布日期:2021-05-17
  • 通讯作者: 李娜，E-mail:xueqian_2525@163.com
  • 作者简介:李娜（1983-），女，医学硕士，副主任医师。研究方向：儿童生长发育和遗传代谢性疾病
  • 基金资助:
    中华国际科学交流基金会检验检测科技专项基金（Z2018LLN001)）；辽宁省科学技术计划项目（2018020167-301）

Research in the nutritional status and serum mineral content of children with autism spectrum disorder

LI Na，LI Xiaofeng，WANG Yang, WEI Huanping，LI Ou，ZHAO Xusheng   

  1. Shenyang Children's Hospital，Shenyang Children's Key Laboratory of Nervous Rehabilitation, Key Laboratory of Shenyang Medical Mass Spectrometry Technology，Shenyang 110032，China
  • Online:2021-02-25 Published:2021-05-17

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摘要： 目的:评估孤独症谱系障碍（ASD）儿童营养状态和血清11种矿物质含量。
方法:选取2019年1～12月在沈阳市儿童医院诊断ASD患儿126例为ASD组和同期于儿童保健科体检儿童200例为对照组。采用电感耦合等离子体质谱法检测血清钙、铁、锌、硒、镁、铜、锰、锂、钴、镍、汞11种矿物质含量。观察两组儿童异常营养状态情况。
结果:ASD组儿童低体质量发生率为8.7%（11/126），高于对照组2.5%（5/200），差异有统计学意义（P＜0.05）；ASD组血清锌/铜、硒、锂低于对照组，铜、锰、汞高于对照组，差异有统计学意义（P<0.01）。
结论:ASD儿童存在微量元素锂、硒缺乏，重金属铜、锰、汞过量现象，临床医生应该重视ASD儿童体内矿物质的平衡，对ASD儿童进行膳食干预和营养指导。

关键词: 孤独症谱系障碍, 血清矿物质, 电感耦合等离子体质谱法, 儿童

Abstract: Objective:To evaluate the nutritional status of children with autism spectrum disorder(ASD) and the content of 11 minerals in serum.
Methods:126 children who were diagnosed with ASD in Shenyang Children's Hospital from January to December，2019 were selected as the ASD group，and another 200 children who were examined in the Child Healthcare Department of Shenyang Children's Hospital during the same period were selected as the control group. The contents of calcium，iron，zinc，selenium，magnesium，copper，manganese，lithium，cobalt，nickel and mercury in serum were determined by Inductively coupled plasma mass spectrometry(ICP-MS).
Results:The incidence of low body weight in ASD group was (8.7%, 11/126), higher than that in control group (2.5%, 5/200)，and the difference was statistically significant (P<0.05). Serum zinc/copper，selenium and lithium in ASD group were lower than those in control group, while copper，manganese and mercury were higher than the control group（P<0.01）.
Conclusion:ASD children have deficiency of trace elements lithium and selenium，and excess of heavy metals copper and mercury. Clinicians should pay attention to the balance of minerals in ASD children，and provide dietary intervention and nutrition guidance to ASD children.

Key words: ASD, Serum minerals, Inductively coupled plasma mass spectrometry, Children