ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (1): 29-.

• 临床研究 • 上一篇    下一篇

小儿热性惊厥与NLR、MPR的相关性探讨

郭美玲，訾慧芬   

  1. 014040 内蒙古 包头，包头医学院2018级儿科学专业研究生（郭美玲）；包头市中心医院儿科（訾慧芬）
  • 出版日期:2021-02-25 发布日期:2021-05-17
  • 通讯作者: 訾慧芬，E-mail：zihuifen bt@126.com
  • 作者简介:郭美玲（1995-），女，包头医学院2018级硕士研究生在读。研究方向：小儿内科疾病的诊治

Study on the relationship between febrile seizures and NLR and MPR in children

GUO Meiling，ZI Huifen   

  1. Department of Pediatrics, Baotou Medical College,Baotou 014040,China
  • Online:2021-02-25 Published:2021-05-17

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摘要： 目的:探讨中性粒细胞/淋巴细胞比率（NLR）、血小板平均体积/血小板计数比率（MPR）与热性惊厥的相关性。
方法:选取2019年10月至2020年12月就诊于包头市中心医院的热性惊厥患儿103例为观察组，同期选取发热未惊厥的急性上呼吸道感染患儿109例作为对照组。分别对两组的血细胞及电解质进行分析，并计算NLR及MPR值。
结果:观察组NLR和MPR显著高于对照组，差异有统计学意义（P<0.05）。观察组血钾、钠低于对照组，差异有统计学意义（P<0.05）；两组血氯、钙比较差异无统计学意义（P>0.05）。NLR、MPR的ROC曲线提示，NLR的最佳临界值为3.79，灵敏度为80.6%，特异度为56.0%；MPR的最佳临界值为0.032 55，灵敏度为72.8%，特异度为53.2%。
结论:NLR和MPR与热性惊厥具有相关性。同时，血清电解质的变化可能也是热性惊厥的重要诱因，其中以血钠、血钾降低为主。

关键词: 热性惊厥, 中性粒细胞/淋巴细胞比率, 血小板平均体积/血小板计数比率, 儿童

Abstract: Objective:To explore the correlation of neutrophil/lymphocyte ratio(NLR) and mean platelet volume/platelet count ratio(MPR) with febrile seizures.
Methods:A total of 103 children with febrile seizures who were admitted to Baotou Central Hospital from October 2019 to December 2020 were selected as the observation group, and 109 children with acute upper respiratory tract infection who had fever without seizures were selected as the control group. The blood cells and electrolytes of the two groups were analyzed respectively, and the NLR and MPR values were calculated.
Results:The NLR and MPR of the observation group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05). The blood potassium and sodium of observation group were lower than those of the control group, and the difference was statistically significant (P<0.05); there was no statistically significant difference in blood chloride or calcium between the two groups(P>0.05). The ROC curves of NLR and MPR indicated that the best critical value of NLR was 3.79, the sensitivity was 80.6%, and the specificity was 56.0%; the best critical value of MPR was 0.032 55, the sensitivity was 72.8%, and the specificity was 53.2%.
Conclusion:NLR and MPR are correlated with febrile seizures. At the same time, changes in serum electrolytes may also be an important cause of febrile seizures, among which blood sodium and potassium are lowered.

Key words: Febrile seizures, Neutrophil/lymphocyte ratio, Mean platelet volume/platelet count ratio, Children