ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (4): 306-.

• 综述 • 上一篇    下一篇

A族溶血性链球菌感染后相关疾病的诊治现状

A族乙型溶血性链球菌（GAS)是革兰阳性球菌，全世界均可发病，儿童发病率高于成人，感染后可引起多种疾病，感染范围从浅表感染（咽炎和局部皮肤感染）,到侵入性感染（GAS感染中毒性休克），也可引起自身免疫性疾病。目前GAS感染的治疗尚未标准化，在急性感染的症状和体征上首选青霉素治疗，而阿奇霉素、红霉素、万古霉素等是对青霉素类过敏的次选药物，经过系统抗感染治疗能够减少远期并发症。   

  1. 110000 沈阳，中国医科大学2018级儿科学专业研究生（杨艳霞）；中国医科大学附属盛京医院小儿心血管内科（王虹）
  • 出版日期:2021-08-25 发布日期:2021-12-10
  • 通讯作者: 王虹，E-mail：wanghong_64@sina.com
  • 作者简介:杨艳霞（1990-），女，医学硕士。研究方向：小儿心血管内科疾病的诊治
  • 基金资助:
    辽宁省科技厅课题（2013225089）

Diagnosis and treatment status of related diseases after group A hemolytic streptococcus infection

Group A hemolytic streptococcus(GAS) is gram-positive cocci, which can cause diseases all over the world. The incidence rate in children is higher than that in adults. After infection, it can cause a variety of diseases. The infection ranges from superficial infections (pharyngitis and local skin infections), to invasive infection (toxic shock due to GAS infection), and it can also cause autoimmune diseases. At present, the treatment for streptococcal infection has not been standardized. Penicillin is the first choice for the symptoms and signs of acute infection. Azithromycin, erythromycin, and vancomycin are theother choice drugs for patients with penicillin allergy. Systemic anti-infection treatment can reduce long-term complications.    

  1. Shengjing Hospital, China Medical University, Shenyang 110000,China
  • Online:2021-08-25 Published:2021-12-10

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摘要： A族乙型溶血性链球菌（GAS)是革兰阳性球菌，全世界均可发病，儿童发病率高于成人，感染后可引起多种疾病，感染范围从浅表感染（咽炎和局部皮肤感染）,到侵入性感染（GAS感染中毒性休克），也可引起自身免疫性疾病。目前GAS感染的治疗尚未标准化，在急性感染的症状和体征上首选青霉素治疗，而阿奇霉素、红霉素、万古霉素等是对青霉素类过敏的次选药物，经过系统抗感染治疗能够减少远期并发症。

关键词: A族乙型溶血性链球菌, 咽炎, 风湿性心脏炎, 关节炎, 肾小球肾炎, 小儿自身免疫性神经精神障碍

Abstract: Group A hemolytic streptococcus(GAS) is gram-positive cocci, which can cause diseases all over the world. The incidence rate in children is higher than that in adults. After infection, it can cause a variety of diseases. The infection ranges from superficial infections (pharyngitis and local skin infections), to invasive infection (toxic shock due to GAS infection), and it can also cause autoimmune diseases. At present, the treatment for streptococcal infection has not been standardized. Penicillin is the first choice for the symptoms and signs of acute infection. Azithromycin, erythromycin, and vancomycin are theother choice drugs for patients with penicillin allergy. Systemic anti-infection treatment can reduce long-term complications. 

Key words: Group A hemolytic streptococcus, Pharyngitis, Rheumatic carditis, Arthritis, Glomerulonephritis, Pediatric autoimmune neuropsychiatric disorders