ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (6): 500-503 .doi: 10.3969/j.issn.1674-3865.2021.06.011

• 临床研究 • 上一篇    下一篇

极早和超早产儿支气管肺发育不良严重程度危险因素分析

高琦, 蒋海燕, 何海英, 刘利军   

  1. 014010 内蒙古 包头，包头医学院2018级儿科学专业研究生（高琦）；014010 内蒙古 包头，包钢集团第三职工医院新生儿科（蒋海燕，何海英，刘利军）

  • 收稿日期:2021-01-08 出版日期:2021-12-25 上线日期:2021-12-25
  • 通讯作者: 刘利军，E-mail：liulijun2008mail@163.com
  • 基金资助:
    包头市科技计划项目（2017S2001-2-2）

Risk factors for the severity of bronchopulmonary dysplasia in very and extremely preterm infants

GAO Qi, JIANG Haiyan, HE Haiying , LIU Lijun   

  1. Baotou Medical College，Baotou 014010，China

  • Received:2021-01-08 Published:2021-12-25 Online:2021-12-25
  • Contact: LIU Lijun，E-mail：liulijun2008mail@163.com

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摘要： 目的 探索影响新生儿重症监护病房极早和超早产儿支气管肺发育不良(BPD)严重程度的危险因素,为防治不同程度的BPD提供理论依据。方法 应用回顾性分析的研究方法,收集2013年12月至2018年12月我院新生儿重症监护病房收治诊断为BPD的胎龄<32周129例极早和超早产儿的临床资料,根据临床诊断标准分为Ⅰ度BPD组(33例)、Ⅱ度BPD组(55例)、Ⅲ度BPD组(41例),通过单因素分析比较组间孕母情况、患儿出生情况、并发症及治疗措施,对单因素分析有统计学意义的因素进行多因素有序Logistic回归分析,探索影响极早和超早产儿BPD严重程度的独立危险因素。结果 单因素分析比较3组患儿出生体质量、肺出血、宫外生长发育迟缓、吸氧浓度>40%、输血次数≥3次、是否高频有创机械通气及有创机械通气时间差异有统计学意义,多因素有序Logistic回归分析得出,肺出血(OR=9.207,95%CI:0.151～4.289)、有创机械通气时间(OR=1.110,95%CI:0.021～0.188)是极早和超早产儿BPD严重程度的独立危险因素。结论 极早和超早产儿发生BPD的严重程度与多因素有关,肺出血、有创机械通气时间是极早和超早产儿BPD严重程度的独立危险因素。积极预防肺出血和减少有创机械通气时间是降低BPD严重程度的重要措施。 

关键词: 支气管肺发育不良, 严重程度, 极早产儿, 超早产儿, 危险因素

Abstract: Objective To explore the risk factors affecting the severity of bronchopulmonary dysplasia(BPD) in very and extremely preterm infants in neonatal intensive care unit(NICU), and to provide theoretical evidence for the prevention and treatment of different degrees of BPD.Methods The research method of retrospective analysis was applied. The clinical data of 129 very and extremely preterm infants with  gestational age <32 weeks diagnosed with BPD in neonatal intensive care unit of our hospital from December 2013 to December 2018 were collected, and the infants were divided into grade Ⅰ BPD(33 cases),grade Ⅱ BPD(55 cases) and grade Ⅲ BPD(41 cases) according to the clinical diagnostic criteria. Univariate analysis was used to compare the maternal status, birth status, complications and treatment measures. To explore the independent risk factors influencing the severity of bronchopulmonary dysplasia in very and extremely preterm infants, multivariate Logistic regression analysis was used to analyze the significant factors of univariate analysis．Results Univariate analysis showed that there were statistically significant difference in birth weight, pulmonary hemorrhage, extrauterine growth retardation,  oxygen inhalation concentration >40%, blood transfusion ≥3 times, high frequency invasive mechanical ventilation and invasive mechanical ventilation time among the three groups. Multivariate Logistic regression analysis showed that pulmonary hemorrhage（OR=9.207,95%CI：0.151～4.289） and invasive mechanical ventilation time （OR=1.110,95%CI：0.021～0.188） were independent risk factors for BPD severity in very and extremely preterm infants.Conclusion The severity of BPD in very and extremely preterm infants is related to multiple factors. Pulmonary hemorrhage and invasive mechanical ventilation time are independent risk factors for BPD severity in very and extremely preterm infants. Prevention of pulmonary hemorrhage and reduction of invasive mechanical ventilation time are important measures to reduce the severity of BPD.

Key words: Bronchopulmonary dysplasia, Severity, Very premature infants, Extremely premature infants, Risk factors