基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制

doi:10.20274/j.cnki.issn.1674-3865.2025.05.007

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (5): 397-401.doi: 10.20274/j.cnki.issn.1674-3865.2025.05.007

基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制

黄鸿勋¹, 李伟伟²()

530022 南宁，广西中医药大学2022级中医儿科学专业研究生（黄鸿勋）
广西中医药大学第一附属医院儿科（李伟伟）

收稿日期:2025-03-14 修回日期:2025-04-25 出版日期:2025-10-25 上线日期:2025-10-25
通讯作者: 李伟伟 E-mail:13878161612@163.com
作者简介:黄鸿勋（1998-），男，广西中医药大学2022级硕士研究生在读。研究方向：儿童肺肾系统疾病及体质与免疫相关研究

Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB

Hongxun HUANG¹, Weiwei LI²()

^1.Guangxi University of Traditional Chinese Medicine, Nanning 530022，China
^2.The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530022，China

Received:2025-03-14 Revised:2025-04-25 Published:2025-10-25 Online:2025-10-25
Contact: Weiwei LI E-mail:13878161612@163.com

摘要/Abstract

摘要：

狼疮性肾炎是系统性红斑狼疮累及肾脏所引起的一种免疫复合性肾炎。狼疮性肾炎的主要表现为自身抗体及其免疫复合物在肾脏沉积，导致慢性炎症浸润和肾脏结构与功能的渐行性破坏，而肾驻留细胞在这一过程中扮演着至关重要的角色。最近研究表明，核因子-κB能够调节炎症进展中多个细胞因子、生长因子和黏附分子的基因表达，如系膜和肾小球上皮细胞中的单核细胞趋化蛋白-1和粒细胞-巨噬细胞集落刺激因子的表达，核因子-κB与狼疮性肾炎的发生发展密切相关，其在靶向调节肾驻留细胞（包括肾脏系膜细胞、足细胞以及肾小管上皮细胞）的生物学反应中发挥着独特作用。在此背景下，本文综述了核因子-κB和肾驻留细胞的关系及其在狼疮性肾炎发病机制中的作用，以期更深入地了解狼疮性肾炎所涉及的潜在细胞和分子机制，为狼疮性肾炎防治中的应用提供理论参考。

关键词: 狼疮性肾炎, 核因子-κB通路, 肾驻留细胞, 作用机制

Abstract:

Lupus nephritis (LN) is an immunocomplex nephritis caused by systemic lupus erythematosus (SLE) involving the kidneys. The main manifestation of LN is the deposition of autoantibodies and their immunocomplexes in the kidneys, which triggers a chronic inflammatory infiltration and the gradual destruction of the structure and function of the kidneys. The renal resident cells play a crucial role in this process. Recent studies have shown that nuclear factor-kappa B (NF-κB) can regulate the gene expression of multiple cytokines, growth factors and adhesion molecules in the progression of inflammation, such as the expression of monocyte chemoattractant protein-1 and granulocyte-macrophage colony-stimulating factors in mesangium and glomerular epithelial cells. NF-κB is closely related to the development of LN and plays a unique role in targeting and regulating the biological responses of renal resident cells, including renal mesangial cells, podocytes and tubular epithelial cells. Against this background, this article reviews the relationship between NF-κB and renal resident cells and their role in the pathogenesis of LN, with an aim to gain a deeper understanding of the underlying cellular and molecular mechanisms involved in LN and provide theoretical references for application in LN prevention and treatment.

Key words: Lupus nephritis, NF-κB pathway, Renal resident cells, Mechanism of action

中图分类号:

R593.24+2

黄鸿勋, 李伟伟. 基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制[J]. 中国中西医结合儿科学, 2025, 17(5): 397-401.

Hongxun HUANG, Weiwei LI. Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(5): 397-401.

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基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制

Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB

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