ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2014, Vol. 6 ›› Issue (2): 119-122.doi: 10.3969/j.issn.1674-3865.2014.02.009

• 论著 • 上一篇    下一篇

哮喘儿童呼出气一氧化氮与肺功能、激发试验、哮喘控制测试评分相关性研究

高虹，刘艳琳，陈燊，董李，华云汉，郭依华，唐素萍   

  1. 350005 福州，福建省福州儿童医院变态反应科
  • 发布日期:2018-11-19
  • 通讯作者: 唐素萍，350005 福州，福建省福州儿童医院变态反应科。
  • 作者简介:高虹（1965-），女，主任医师。研究方向：小儿急救、过敏性疾病的诊治。
  • 基金资助:
    福建省自然科学基金计划项目（2009J01322）

The study of fractional exhaled nitric oxide(FeNO) and its relationship with lung function, exercise challenge test, CACT score in the children with asthma

GAO Hong，LIU YanLin, CHEN Shen, et al.   

  1. Department of Allergy of Fuzhou Children's Hospital，Teaching Hospital of Fujian Medical University，Fuzhou 350005，China.
  • Published:2018-11-19

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摘要：
目的:探讨哮喘儿童急性发作期和临床缓解期呼出气一氧化氮（FeNO）水平与肺功能（FEV1）、儿童哮喘控制测试（CACT）评分的相关性，临床缓解期哮喘儿童FeNO水平与运动激发试验的相关性。
方法:哮喘儿童急性发作期135例（发作期组），临床缓解期115例（缓解期组），健康体检儿童140例（对照组），均进行FeNO测定、FEV1检测和CACT评分，分析哮喘不同时期FeNO水平与FEV1、CACT是否存在相关性。同时临床缓解期哮喘儿童进行运动激发试验，分析缓解期FeNO水平与运动激发试验是否存在相关性。
结果:（1）发作期组FeNO、FEV1与对照组比较差异有统计学意义（P＜0.000 1）；发作期组FeNO、FEV1与缓解期组比较差异有统计学意义（P＜0.000 1）；缓解期组FeNO与对照组比较差异有统计学意义（P＜0.000 1），而FEV1与对照组比较差异无统计学意义（P>0.05）。（2）发作期组FeNO与FEV1之间存在负相关（r=-0.181，P=0.035），缓解期组及对照组的FeNO与FEV1之间无相关性。（3）缓解期组FeNO与运动激发试验之间存在正相关（r=0.230，P=0.013）。（4）发作期组、缓解期组FeNO与CACT评分之间存在负相关（r=-0.213，-0.209，P=0.013，0.025）。
结论:哮喘儿童FeNO水平可用于评估哮喘病情的控制程度。运动激发试验是评估哮喘气道高反应的另一简易测定方法。

关键词: 哮喘, 一氧化氮, 肺功能, 运动激发试验, 儿童

Abstract:
Objective:To investigate the levels of fractional exhaled nitric oxide(FeNO) and their relationship with lung function（FEV1）,CACT score of the children with asthma in acute onset and paracmasis periods and the relationship between FeNO level and exercise challenge test in the children with asthma in paracmasis period.
Methods:A total of 135 cases of asthma in acute onset, 115 cases in paracmasis and 140 cases of healthy children were selected from Department of Allergy in our hospital. All subjects were determined for FeNO, lung function（FEV1） and CACT score, and the FeNO level correlation with lung function (FEV1) and CACT score in the various period of asthma were analyzed. At the same time, clinical paracmasis in asthma children had exercise challenge test, and the relationship of FeNO level in paracmasis with exercise challenge test was analyzed.
Results:(1) There were significant differences between the asthma acute onset group and the control group in the levels of FeNO and FEV1（P＜0.000 1）.There were significant differences between the asthma acute onset group and the paracmasis group in the levels of FeNO and FEV1（P＜0.000 1）.There were significant differences between the paracmasis group and the control group in the levels of FeNO（P＜0.0001）.There were no significant differences between the paracmasis group and the control group in the levels of FEV1（P>0.05）.(2) The negative correlation between FeNO and FEV1 was found in the asthma acute onset group（r=-0.181，P=0.035）, but not in the paracmasis group and the control group.(3) The positive correlation between FeNO and exercise challenge test was found in the paracmasis group（r=0.230，P=0.013）.(4) The negative correlation between FeNO and CACT score was found in the asthma acute onset group and the paracmasis group（r=-0.213，P=0.013，r=-0.209，P=0.025）.
Conclusion:The levels of FeNO may be useful to evaluate and control degree in patients with asthma. Exercise challenge test is a simple method of assessing asthma airway hyperresponsiveness.

Key words: asthma, nitric oxide, lung function, exercise challenge test, children