ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (2): 138-140.doi: 10.3969/j.issn.1674-3865.2017.02.015

• 临床研究 • 上一篇    下一篇

更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎的疗效观察

靳燕霞   

  1. 462300 河南 漯河,漯河市郾城区人民医院儿科
  • 出版日期:2017-04-25 发布日期:2017-12-18
  • 作者简介:靳燕霞(1972—)，女，副主任医师。研究方向：儿科呼吸系统疾病的诊治，E-mail:hfnsoif@126.com

Clinical effect of Ganciclovir in the treatment of children with epidemic parotitis complicated with meningitis

JIN Yanxia   

  1. Pediatric Department, Yancheng District People's Hospital，Luohe 462300，China
  • Online:2017-04-25 Published:2017-12-18

PDF (PC)

100

摘要：


目的更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎的疗效。
方法选取2014年7月至2015年6月漯河市郾城区人民医院134例小儿流行性腮腺炎合并脑膜炎患儿为研究对象，随机分为观察组与对照组各67例。对照组采用常规对症治疗；观察组则在对照组对症治疗基础上，采用更昔洛韦进行治疗，两组疗程均为6 d，分析对比两组治疗后临床症状及体征改善效果及临床疗效。
结果通过采用不同治疗方案，观察组及对照组治疗总有效率分别为9851%(66/67)、8060%(54/67)，两组比较差异有统计学意义(P<005)；观察组退热时间与对照组比较差异无统计学意义(P>005)；观察组治疗后头痛消失、腮腺肿大消退、神经症状缓解、平均住院时间均优于对照组，差异有统计学意义(P<005)。
结论〗采用更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎疗效较好，可有效减轻临床不良症状，提升治疗效果，具备临床意义与价值。

关键词: 流行性腮腺炎, 更昔洛韦, 脑膜炎, 儿童

Abstract: Objective：To explore the clinical effect of Ganciclovir in the treatment of children with epidemic parotitis complicated with meningitis.
Methods：Totally 134 children with epidemic parotitis complicated with meningitis treated from July 2014 to June 2015 in our hospital were selected. The subjects were randomly divided into two groups: observation group(A) and control group(B), 67 cases in each group. Group B was treated with conventional treatment, while for group A, on the basis of routine treatment, they were treated with ganciclovir. The treatment lasted for 6 days for both groups. Compare and analyze the improvement of clinical signs and symptoms and the clinical effect after treatment between the two groups.
Results：The total effective rate of group A(98.51%,66/67) was better than that of group B(80.60%,54/67) with statistical difference(P＜0.05). The fewer disappearance time after treatment in group A showed no statistical difference compared with group B(P >0.05). After treatment, with regard to headache disappearance, parotid swelling subsidence, neurological symptoms remission and average hospitalization stay group A was better than group B, and the difference between the two groups was of statistical significance(P<0.05).
Conclusion：For epidemic parotitis children complicated with meningitis, Ganciclovir can effectively improve the clinical effect and reduce the adverse event rate. It is of great importance in clinical practice.

Key words: Epidemic parotitis, Ganciclovir, Meningitis, Children