ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 318-321.doi: 10.3969/j.issn.1674-3865.2019.04.012

• 临床研究 • 上一篇    下一篇

极低出生体重儿心脏迷走神经张力和学龄期发育结局的相关性分析

左磊，张营营，赵杰   

  1. 518000 广东 深圳，中山大学附属第八医院新生儿科
  • 收稿日期:2019-04-03 出版日期:2019-08-25 上线日期:2019-08-25
  • 通讯作者: 左磊，E-mail：renshenguo124@16.com
  • 作者简介:左磊(1984-)，男，主治医师。研究方向：儿科急救、新生儿疾病的诊治

Analysis of the relationship between cardiac vagal tone and school-age developmental outcome in very low birth weight infants

ZUO Lei，ZHANG Yingying，ZHAO Jie   

  1. The Eighth Hospital Affiliated to Sun Yat-sen University，Shenzhen 518000，China
  • Received:2019-04-03 Published:2019-08-25 Online:2019-08-25
  • Contact: ZUO Lei，E-mail：renshenguo124@16.com

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摘要： 目的探讨极低出生体重儿(VLBWI)心脏迷走神经张力和学龄期发育结局的相关性分析。方法选择2007年5月至2010年5月中山大学附属第八医院重症监护病房收治的VLBWI患儿60例进行分析，于33~35周孕龄进行呼吸性窦性心律失常(RSA)成熟评分，并记录其他生理指标，探讨其与学龄期发育结局的相关性分析。结果 学龄期发育结局与出生后3年的发育结局密切相关，多元回归分析结果显示，VLBWI RSA成熟程度与学龄期的社交能力相关。结论 通过RSA测量可早期评估中枢神经系统自我调节能力及预测学龄期发育结局。

关键词: 极低出生体重儿, 心脏迷走神经张力, 学龄期, 发育结局

Abstract: ObjectiveTo investigate the correlation between cardiac vagal tone and school-age developmental outcome in very low birth weight infants(VLBWI).Methods This study analyzed 60 VLBWI admitted to our neurological intensive care unit(NICU) from May 2007 to May 2010. The respiratory sinus arrhythmia(RSA) maturity scoring was performed at 33 to 35 weeks of gestational age, and other physiological indicators were recorded, to explore its correlation with the developmental outcome at school age. Results The school-age developmental outcome was closely related to the developmental outcome at 3 years after birth. Multiple regression analysis showed that the VBAWI RSA maturity was related to the social ability at school age.
ConclusionRSA measurements can be used to early assess central nervous system self-regulation and predict school-age developmental outcomes.

Key words: Very low birth weight infants, Cardiac vagal tone, School age, Developmental outcome