ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (5): 381-383.

• 综述 • 上一篇    下一篇

维生素A缺乏致小儿贫血的机制研究进展

维生素A是人类机体必不可少的脂溶性维生素，特别是在儿童、妊娠及哺乳期妇女中。儿童时期缺乏维生素A可导致干眼症，降低机体抵抗力，增加机体感染的风险。维生素A缺乏导致儿童贫血的机制包括：限制造血基因表达、红细胞膜的稳定性遭到破坏、减少促红细胞生成素水平进而抑制造血、影响机体铁代谢，减少造血原材料的提供等，本文就维生素A缺乏导致儿童贫血的发病机制做一简要综述。   

  1. 110000 沈阳，沈阳市儿童医院小儿血液科
  • 出版日期:2021-10-25 发布日期:2021-11-17
  • 通讯作者: 穆亚平，E-mail:sysetyy8101@126.com
  • 作者简介:王海伟（1992-），男，医学硕士。研究方向：小儿血液系统疾病的诊治

Research progress in the mechanism of vitamin A deficiency causing anemia in children

Vitamin A is an essential fat-soluble vitamin in human body, especially to children, pregnant and lactating women. Vitamin A deficiency in childhood is known to cause dry eyes, lower body resistance and increase the risk of infection.The pathogenesis of anemia in children caused by vitamin A deficiency includes restriction of hematopoietic gene expression, destruction of erythrocyte membrane stability, reduction of EPO level and hematopoietic inhibition, influence on iron metabolism, and reduction of hematopoietic raw materials, etc. This paper summarizes the pathogenesis of anemia caused by vitamin A deficiency in children.   

  1.  Shenyang Children's Hospital，Shenyang 110000，China
  • Online:2021-10-25 Published:2021-11-17

PDF (PC)

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摘要： 维生素A是人类机体必不可少的脂溶性维生素，特别是在儿童、妊娠及哺乳期妇女中。儿童时期缺乏维生素A可导致干眼症，降低机体抵抗力，增加机体感染的风险。维生素A缺乏导致儿童贫血的机制包括：限制造血基因表达、红细胞膜的稳定性遭到破坏、减少促红细胞生成素水平进而抑制造血、影响机体铁代谢，减少造血原材料的提供等，本文就维生素A缺乏导致儿童贫血的发病机制做一简要综述。

关键词: 维生素A, 贫血, 维生素A缺乏, 公共卫生

Abstract: Vitamin A is an essential fat-soluble vitamin in human body, especially to children, pregnant and lactating women. Vitamin A deficiency in childhood is known to cause dry eyes, lower body resistance and increase the risk of infection.The pathogenesis of anemia in children caused by vitamin A deficiency includes restriction of hematopoietic gene expression, destruction of erythrocyte membrane stability, reduction of EPO level and hematopoietic inhibition, influence on iron metabolism, and reduction of hematopoietic raw materials, etc. This paper summarizes the pathogenesis of anemia caused by vitamin A deficiency in children.

Key words: Vitamin A, Anemia, Vitamin A deficiency, Public health