“靳三针”针法与认知功能训练辅助经颅直流电刺激对发育迟缓患儿的临床疗效

doi:10.20274/j.cnki.issn.1674-3865.2026.04.016

摘要/Abstract

摘要：

目的观察“靳三针”针法与认知功能训练辅助经颅直流电刺激（tDCS）用于发育迟缓患儿的临床疗效。方法回顾性分析2021年6月至2025年6月驻马店市第一人民医院收治的发育迟缓患儿84例。根据是否接受“靳三针”针法治疗将84例患儿分为观察组45例和对照组39例。对照组患儿接受认知功能训练和tDCS干预，观察组在对照组治疗基础上采用“靳三针”针法，两组均连续干预3个月。干预前后采用Gesell发育量表评估两组患儿智力水平，采用粗大运动发育量表（GMFM-88）与Peabody精细运动发育量表（PDMS-FM）评估运动功能，采用酶联免疫吸附试验法检测血清学指标水平，记录不良反应发生率。结果干预后观察组智力水平优于对照组，差异有统计学意义（P<0.05）。干预后两组GMFM-88和PDMS-FM评分、血清脑源性神经营养因子（BDNF）与神经生长因子（NGF）水平较干预前均显著升高，且干预后观察组各评分高于对照组，差异均有统计学意义（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论 “靳三针”针法与认知功能训练，辅助tDCS用于肝肾亏虚证发育迟缓患儿具有一定疗效，有助于促进智力发育，改善运动功能。

关键词: 发育迟缓, 肝肾亏虚证, 靳三针针法, 认知功能训练, 经颅直流电刺激

Abstract:

Objective To observe the clinical efficacy of "Jin's Three-Needle Therapy" combined with cognitive function training-aided transcranial direct current stimulation (tDCS) in children with developmental delay. Methods A retrospective analysis was performed on 84 children with developmental delay admitted to Zhumadian First People's Hospital from June 2021 to June 2025.According to whether they received "Jin's Three-Needle Therapy" or not, the 84 children were divided into observation group (n=45) and control group (n=39).The children in the control group received cognitive function training and tDCS intervention, while children in the observation group were additionally treated with "Jin's Three?Needle Therapy" on the basis of the control group's regimen; the two groups received continuous intervention for 3 months.The Gesell Developmental Scale was used to assess the intellectual level of children in the two groups before and after intervention,the Gross Motor Function Measure?88 (GMFM?88) and Peabody Developmental Motor Scales?Fine Motor (PDMS?FM) were adopted to evaluate motor function, and the enzyme?linked immunosorbent assay was used to detect the levels of serological indicators. The incidence of adverse reactions was recorded. Results After intervention, the intellectual level in the observation group was superior to that of the control group,and the difference was statistically significant (P<0.05).After intervention, the GMFM?88 and PDMS?FM scores, as well as serum levels of brain?derived neurotrophic factor (BDNF) and nerve growth factor (NGF), were significantly increased compared with those before intervention in the two groups. Moreover, all scores in the observation group were higher than those in the control group after intervention, with statistically significant differences (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The "Jin's Three?Needle Therapy" combined with cognitive function training as an adjunct to tDCS yields certain therapeutic effects on children with developmental delay of liver?kidney deficiency syndrome, which helps promote intellectual development and improve motor function..

Key words: Developmental delay, Liver-kidney deficiency syndrome, Jin's Three-Needle Therapy, Cognitive function training, Transcranial direct current stimulation

中图分类号:

R339.3+5

朱景菊, 李明霞, 王明霞, 冯建楠. “靳三针”针法与认知功能训练辅助经颅直流电刺激对发育迟缓患儿的临床疗效[J]. 中国中西医结合儿科学, 2026, 18(4): 353-357.

Jingju ZHU, Mingxia LI, Mingxia WANG, Jiannan FENG. Clinical efficacy of "Jin's Three‑Needle Therapy" combined with cognitive function training‑aided transcranial direct current stimulation in children with developmental delay[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(4): 353-357.

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组别	n	性别（男/女）	年龄（x±s，岁）	分娩方式		新生儿窒息
组别	n	性别（男/女）	年龄（x±s，岁）	顺产	剖宫产	新生儿窒息
对照组	39	20/19	4.84±1.02	24	15	12
观察组	45	25/20	4.76±1.20	22	23	18

组别	n	干预前				干预后
组别	n	发育正常	边缘状态	轻度发育迟缓	中度发育迟缓	发育正常	边缘状态	轻度发育迟缓	中度发育迟缓
对照组	39	0（0）	14（35.9）	5（12.8）	20（51.3）	2（5.1）	18（46.2）	7（17.9）	12（30.8）
观察组	45	0（0）	10（22.2）	9（20.0）	26（57.8）	6（13.3）	25（55.6）	10（22.2）	4（8.9）

组别	n	GMFM-88评分		PDMS-FM抓握能力		PDMS-FM视觉-运动系统
组别	n	干预前	干预后	干预前	干预后	干预前	干预后
对照组	39	40.12±8.93	46.54±9.39^a	41.35±5.85	45.29±6.16^a	80.32±14.43	86.34±9.27^a
观察组	45	38.74±10.06	51.29±7.61^a	40.16±6.28	50.42±5.05^a	78.48±16.62	92.08±14.26^a
t值		0.660	2.560	0.894	4.193	0.538	2.150
P值		0.511	0.012	0.374	<0.001	0.592	0.035

组别	n	血清BDNF		血清NGF
组别	n	干预前	干预后	干预前	干预后
对照组	39	19.86±6.32	26.53±4.14^a	20.12±4.32	25.57±5.60^a
观察组	45	20.91±4.45	32.07±3.59^a	18.69±3.96	34.06±3.32^a
t值		0.889	6.569	1.582	8.582
P值		0.377	<0.001	0.117	<0.001

组别	n	局部红斑、瘙痒	局部疼痛	晕针	总发生
对照组	39	4（10.26）	1（2.56）	0（0.00）	5（12.82）
观察组	45	3（6.67）	2（4.44）	2（4.44）	7（15.56）