ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (6): 495-497.doi: 10.3969/j.issn.1674-3865.2017.06.011

• 临床研究 • 上一篇    下一篇

TRPC1在儿童肝母细胞瘤中的表达与临床病理特征及预后的关系

黄召，李勇，刘登辉，肖雅玲   

  1. 410007 长沙，湖南省儿童医院普外二科
  • 出版日期:2017-12-25 发布日期:2018-11-19
  • 通讯作者: 肖雅玲，E-mail：etyypwk@sina.com
  • 作者简介:黄召（1986-），男，医学硕士，医师。研究方向：小儿胃肠、肝胆、肿瘤疾病的诊治

Relationship of the expression of TRPC1 with clinicopathological parameter and prognosis of hepatoblastoma in children

HUANG Zhao，LI Yong，LIU Denghui，XIAO Yaling   

  1. Hunan Children's Hospital, Changsha 410007,China
  • Online:2017-12-25 Published:2018-11-19

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摘要：
目的
检测TRPC1在儿童肝母细胞瘤组织中的表达，分析其与临床病理特征及预后的关系。
方法
收集湖南省儿童医院普外科自2008年1月至2015年12月行肝脏肿块切除的16例肝母细胞瘤患儿的病理资料和临床资料，采用免疫组织化学法检测TRPC1在儿童肝母细胞瘤组织中的表达情况，并分析其与临床病理特征（肿瘤组织与非肿瘤组织、肿瘤的大小）的关系，随访3～5年分析其与预后的关系。
结果
TRPC1在16例肝母细胞瘤患儿癌组织中表达程度不同，高表达占62.5%（10/16），低表达占37.5%（6/16）。TRPC1高表达与肝母细胞瘤临床病理特征中的肿瘤组织与非肿瘤组织、肿瘤大小比较差异有统计学意义（P<0.05）；患儿3年生存率为72.73%（8/11），5年生存率为50%（3/6）。TRPC1表达与3年、5年生存率比较差异无统计学意义（P>0.05）。
结论
TRPC1表达可能与儿童肝母细胞瘤的发生、发展有关，但不一定与预后有关。

关键词: 肝母细胞瘤, TRPC1, 免疫组织化学, 临床病理特征, 预后, 儿童

Abstract:
Objective
To defect the expression of TRPC1 in the tissues of hepatoblastoma and to analyze its relationship with clinicopathological features and prognosis.
Methods
The pathological data and clinical data of 16 children with hepatoblastoma(HB) were collected, who underwent hepatectorny in Hunan Children's Hospital from Jan. 2008 to Dec. 2015. The expression of transient receptor potential channel-related protein 1(TRPC1) in HB tissues was detected by immunohistochemistry, its relationship with clinicopathological features(neoplastic tissues and non-neoplastic tissues, the sizes of neoplasm) was analyzed, and its relationship with prognosis was analyzed in the 3 to 5 years of follow-up.
Results
The expression of TRPC1 in the 16 HB children was different, with high expression accounting for 62.5%(10/16) and low expression 37.5%(6/16).The high expression of TRPC1 had statistical difference in the neoplastic and non-neoplastic tissues and in the sizes of neoplasms(P<0.05).The 3-year survival rate was 72.73%(8/11),and the 5-year was 50%(3/6).There was no statistical significance in TRPC1 expression comparing 3-year with 5-year survival rate(P>0.05).
Conclusion
The expression of TRPC1 may be related to the development and progression of HB in children, but it may be irrelevant to prognosis.

Key words: Hepatocastoma, TRPC1, Immunohistochemistry, Clinicopathological festures, Prognosis, Child