ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2013, Vol. 5 ›› Issue (1): 9-11.doi: 10.3969/j.issn.1674-3865.2013.01.003

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消斑愈肾复方对IgA肾病大鼠肾组织白细胞介素13及血清循环复合物的影响

于超，张君，王圣治，杨冠琦   

  1. 110032 沈阳，辽宁中医药大学研究生学院（于超，杨冠琦）；辽宁中医药大学附属医院儿科（张君），肾内科（王圣治）
  • 收稿日期:2012-12-25 出版日期:2013-02-25 上线日期:2019-02-25
  • 通讯作者: 张君
  • 作者简介:于超(1986-），女，辽宁中医药大学2010级硕士研究生在读。研究方向：中医药防治小儿肾炎。
  • 基金资助:
    科技部重大新药创制专题（2009ZX09103）

Influence of Xiaoban Yushen compound on renal tissue IL-13 and CIC in serum of rats with IgA nephropathy

YU Chao,ZHANG Jun,WANG Sheng zhi   

  1. The Graduate School of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，China
  • Received:2012-12-25 Published:2013-02-25 Online:2019-02-25

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摘要： 目的:观察消斑愈肾复方对IgA肾病大鼠肾组织白细胞介素13（IL-13）的表达及血清循环复合物（CIC）浓度的影响，探讨其治疗IgA肾病的机制。方法:SD大鼠40只随机分为正常组、模型组、替米沙坦组和消斑愈肾复方组，每组各10只。采用口服牛血清白蛋白制备实验性IgA肾病大鼠模型。消斑愈肾复方及替米沙坦于实验第8周开始灌胃给药，每日1次，连续5周，至实验12周末取血检测循环免疫复合物含量，取肾脏组织检测IL-13表达。结果:与模型组比较，消斑愈肾复方组IL-13表达和血清CIC浓度均下降，差异有统计学意义（P<0.01）；与替米沙坦组比较，消斑愈肾复方组IL-13表达和血清CIC浓度下降，差异有统计学意义（P<0.05）。结论:消斑愈肾复方有调节IgA肾病大鼠肾组织IL-13表达及血清CIC浓度的作用。

Abstract: Objective：To observe the effect of Xiaoban Yushen compound on renal tissue IL-13 expression and circulating immune complexes(CIC) serum concentration and to study the mechanism of its treatment for IgA nephropathy.Methods：The rats were randomized into normal group，model group，telmisartan group and Xiaoban Yushen compound group, with 10 rats in each group．Bovine serum albumin(BSA) was taken orally to make experimental IgA nephropathy rat model. Xiaoban Yushen compound and telmisartan were given at the eighth week of the experiment for gavage, once daily for five consecutive weeks; at the end of the 12th week, blood was taken to detect immune complexes content, and kidney tissue was taken to detect IL-13 expression.Results：Compared with the model group, IL-13 expression and serum concentration of CIC in Xiaoban Yushen compound group decreased (P<0.01); compared with telmisartan group, IL-13 expression and serum CIC concentration in Xiaoban Yushen compound group decreased (P<0.05); both differences had statistic significance.Conclusions：Xiaoban Yushen compound plays a role in regulating IL-13 expression in renal tissue and serum CIC concentration of IgA nephropathy.