Abstract:
Objective
Children with Kawasaki disease need long-term oral aspirin, Long term application of aspirin can cause gastric mucosal damage. Aspirin and Helicobacter pylori infection are the two most common gastric mucosal damage factors. This study uses the method of Helicobacter pylori stool antigen test to explore interaction between children's oral smalldose aspirin and Helicobacter pylori(Helicobacter pylori, Hp) infection in children with Kawasaki disease in order to provide a reference for clinical treatment.
Methods
Totally 101 cases of Kawasaki disease were selected, who require longterm low-dose oral aspirin for at least 3 months, from July 2016 to June 2018.They were divided into Hp-positive group(27) and Hpnegative group(74). Before eradication treatment, the symptom scoring of digestive system was made. The Hppositive patients received Hp eradication, who took amoxicillin, clarith romycin and omeprazole orally to eradicate Hp for 10 days. One month after stopping the medication, the scoring was made again, and Hp stool antigen was detected again. After successful Hp eradication in the Hppositive group, the symptom scoring of digestive system was performed again.
Results
There was statistical difference in the symptom scores between Hp-positive group and Hpnegative group before eradication treatment(P<0.05). After the treatment, the stool antigen was negative in 22 cases in the Hp-positive children, which was considered that the eradication treatment was successful. The treatment failed in 5 cases. There was no statistical difference in the digestive score between Hp-positive children after the treatment and Hp-negative children(P>0.05).
ConclusionAspirin and Hp have a synergistic effect on gastric mucosal injury. It is suggested that children with long-term use of aspirin receive Hp-eradication treatment.

Key words: Kawasaki disease, Helicobacter pylori stool antigen detection, Children