Abstract:
Objective
To observe the clinical effect of pulmicort respulas and ventolin combined with methylprednisolone in the treatment of children with bronchiolitis.
Methods
A total of 118 children with bronchiolitis were included in the study, who were treated in the Pediatric Department of Gongyi People's Hospital from Oct. 2013 to Oct. 2016. They were randomly divided into two groups：59 in observation group and 59 in control group. After admission to the hospital, they were given oxygen inhalation, antitussive and antiviral treatment, and those with viral infection were given antibiotic. In addition, the children in control group received budesonide suspension(plumicort respulas)(1 mg) and salbutamol sulfate inhalation aerosol(ventolin)(0.5 mL), which was mixed with normal saline(2 mL). Then it was inhaled by oxygen-driven method for about 10 minutes, once every eight hours, for continuously one week. The children in the observation group received the same treatment; besides, methylprednisolone injection was given through venous dripping,1～2 mg/kg, twice a day, for 3 day as a course. Observe the effect of the two groups, as well as the time for cough, asthma, wheezing and pulmonary rales to be relieved, determine the concentration of MCP-4 and follow up the incidence of adverse effects.
Results
The total effective rate in observation group was 98.3%(58/59),significantly higher than that in control group 86.4%(51/59), and the difference was statistically significant(P<0.05). The time for cough, asthma, wheezing and pulmonary rales to be relieved in the observation group was short than that in control group, and there was statistical difference(P<0.05). Concentration of MCP-4 decreased in both groups after treatment, which was even lower in the observation group(P<0.05). There was one case of hoarseness in the control group, while there was no adverse effect in the observation group, there being no statistical difference(P>0.05).
Conclusion
Pulmicort respulas and ventolin combined with methylprednisolone has significant effect in the treatment of children with bronchiolitis, and can shorten the time of relieving symptoms, which is currently safe and reliable, and worth promotion.

Key words: Bronchiolitis, Pulmicort respulas, Ventolin, Methylprednisolone, Effect, Child