Abstract: Objective:To investigate Neurocan and Versican expression in white matter of the newborn rats with brain damage caused by intrauterine infection.Method:Forty pregnant female rats were randomly divided into control group (n=10) and LPS group (n=30).The rats in LPS group were intraperitoneally administered LPS (serotype 055) 450μg/kg in two consecutive days,and the rats in control group were intraperitoneally administered physiological saline in the same dose.The offsprings were killed respectively at 0 day,1 day,1 week,2 weeks,3 weeks and 4 weeks after birth;pathological changes of brain tissue were observed by HE staining，and the relative content of the neurocan and versican were measured by fluorescence quantitative R-PCR.Results:(1)There were no death of pregnant rats and early birth in control group,and parturition of live births and full-term pups were 124;5 pregnant rats in LPS group were dead,6 early delivery,and 132 were delivered full-rm and live births,death 24.(2)Neurocan mRNA and versican mRNA expression in white matter of LPS group were increased significantly at 0 day,1 day,1 week,2 weeks,3 weeks and 4 weeks,respectively (P<0.05).Conclusion:Neurocan and versican expression are increased significantly after brain injury induced by intrauterine infection.

Key words: Brain demage, Neurocan；Periventricular histomalacia, Cerebral disease, Rat,newborn, Animal,experiment