Abstract:
Objective
To study the clinical effect of montelukast sodium and budesonide in children with cough-variant asthma.
Methods
A total of 140 children with cough-variant asthma treated from July 2014 to June 2015 in our hospital were selected. The subjects were divided into two groups according to the different therapies, 70 cases in each group. Group B took budesonide; group A took the combined therapy of montelukast sodium and budesonide; the treatment lasted for 12 days. The clinical effect for two groups was analyzed, and observe the indexes related to pulmonary function:FEV1, PEF and FEV1/FVC.
Results
The total effective rate of the observation group was 98.6%(69/70), significantly higher than that of control group(77.1%,54/70), and there was statistical difference(P<0.05).Before treatment,there was no statistical difference in such pulmonary indexes as FEV1,PEF or FEV1/FVC between the observation and control group(P>0.05), but after treatment these indexes were significantly higher in the observation group than in the control group with statistical difference(P<0.05).
Conclusion
The combined therapy of montelukast sodium and budesonide can efficiently improve the clinical effect in the treatment of children with cough-variant asthma, which is worthy of clinical application.

Key words: Cough-variant asthma, Montelukast sodium, Budesonide, Children