EV71型IgG、IgM和IgA抗体在手足口病诊断中的意义

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 231-233.

Significance of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease

Objective: To explore the application value of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease.#br# Methods :Totally 116 cases of children with hand-foot-mouth disease(HFMD) infected with EV71 who were treated in our hospital from March 2019 to March 2020 were selected, and the type of virus was detected by real-time fluorescent quantitative PCR, and the EV71 IgG, IgM and IgA antibodies were detected by immunochromatography.#br# Results: The positive rates of EV71 IgG, IgM and IgA antibodies were 62.07%(72/116), 68.10%(79/116) and 60.34%(70/116), respectively,and the positive rate of EV71 nucleic acid test was 72.41%(84/116), the difference being not statistically significant(P>0.05).The positive rate of EV71 IgM and IgG antibody in mild children was lower than that in severe children,and the difference was statistically significant(P<0.01).#br# Conclusion: The diagnostic ability of the detection of EV71 IgG, IgM and IgA antibodies in hand-foot-mouth disease is good; the positive rate of IgM and IgG antibody of severe EV71 is higher than that of common children, which suggests that it has clinical application value for early diagnosis and symptomatic treatment of the disease.

Department of Laboratory of Quality Management,Pingdi Preventive Health Care Center of Longgang District, Shenzhen 518117,China

Online:2021-06-25 Published:2021-12-15

Abstract

Abstract: Objective: To explore the application value of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease.
Methods :Totally 116 cases of children with hand-foot-mouth disease(HFMD) infected with EV71 who were treated in our hospital from March 2019 to March 2020 were selected, and the type of virus was detected by real-time fluorescent quantitative PCR, and the EV71 IgG, IgM and IgA antibodies were detected by immunochromatography.
Results: The positive rates of EV71 IgG, IgM and IgA antibodies were 62.07%(72/116), 68.10%(79/116) and 60.34%(70/116), respectively,and the positive rate of EV71 nucleic acid test was 72.41%(84/116), the difference being not statistically significant(P>0.05).The positive rate of EV71 IgM and IgG antibody in mild children was lower than that in severe children,and the difference was statistically significant(P<0.01).
Conclusion: The diagnostic ability of the detection of EV71 IgG, IgM and IgA antibodies in hand-foot-mouth disease is good; the positive rate of IgM and IgG antibody of severe EV71 is higher than that of common children, which suggests that it has clinical application value for early diagnosis and symptomatic treatment of the disease.

Key words: Hand foot-mouth-disease, EV71；IgG antibody, IgM antibody, IgA antibody, Children

LAI Fang, WEN Huanyu, LIANG Xueyan. Significance of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(3): 231-233.

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Significance of EV71 IgG, IgM and IgA antibodies in the diagnosis of hand-foot-mouth disease

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