Abstract: Objective: To understand the viral pathogen composition and epidemic characteristics of children aged 0-14 year old with acute respiratory tract infection(ARTI) in Lanzhou city from 2017 to 2018, and to provide clinical basis for the diagnosis and prevention of ARTI in children.Methods: A total of 188 pharyngeal swabs of children with ARTI were collected from outpatient department, whichmeet the inclusion criteria, in Lanzhou University Second Hospital from October 2017 to September 2018. Capillary electrophoresiswas used to detect Influenza virus(IFV)A and B(IFVA, IFVB), respiratory syncytial virus(RSV)A and B(RSVA, RSVB), parainfluenza virus (PIV)1.4(PIV1.4), adenovirus(ADV), human metapneumonia virus(HMPV), human bocavirus(HBoV), rhinovirus/human enterovirus(HRV/HEV), and human coronavirus(HCoV). Results: At least one kind of viruses was detected in 173 out of 188 cases, the overall positive rate was 92.02%. The positive rate of RVS was highest with a value of 34.0% (64/188), followed by IFV 30.9% (58/188), PIV 22.9% (43/188), ADV 19.1%（36/188）, HRV/HEV 10.6%（20/188）, HCoV 7.4%（14/188）, HBoV 3.2%（6/188）and HMPV 2.1%（4/188）. There were 44 cases(23.4%) of mixed infectionof two or more kinds of viruses. There was no significant seasonal difference in the positive rate of RSV, IFV and ADV, and the positive rate of PIV, HRV/HEV and HCoV was significantly increased. The positive rate of respiratory virus in children under 1 year old was the highest, reaching 100.0%. Conclusion: Child ARTI in Lanzhou city from October 2017 to September 2018 are mainly caused by RSV, IFV, PIV and ADV, and should be controlled through the whole year. Virus infection is the main pathogen at early stages of child ARTI under 1 year old, and the routine use of antimicrobial agents is not appropriate.

Key words: Acute respiratory infection, Viruses, Lanzhou city, Children