Abstract:

Objective By analyzing the clinical characteristics of Kawasaki disease(KD) complicated with influenza virus infection, to further improve the clinicians' understanding of the etiology of Kawasaki disease. Methods A total of 57 children with Kawasaki disease hospitalized in our hospital from June 2010 to December 2019 were selected. Children with KD and influenza virus infection were selected as experiment group(n=19)，and children with KD alone were selected as control group(n=38). The clinical manifestations and laboratory test indexes were compared, including white blood cell(WBC),hemoglobin(Hb),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),neutrophilic granulocyte percentage(N%),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatine kinase-MB(CK-MB).The therapeutic effect of intravenous immunoglobulin(IVIG) and incidence of coronary artery injury were also analyzed.Results Fever days in experiment group were longer than those in control group. ESR,CRP,ALT and CK-MB levels in experiment group were all higher than those in control group,and the difference was statistically significant(P<0.05).The no-response rate to first-time IVIG, and the incidence of coronary artery injury in experiment group were higher than those in the control group.Conclusion The occurrence of KD may be associated with immune dysfunction caused by influenza virus.

Key words:

Kawasaki disease(KD), Influenza virus, Coronary artery