Abstract:

The prevention and treatment strategy of epilepsy has shifted from controlling epileptic seizures to controlling epileptogenesis. Epileptogenesis is the budding and early stage of child epilepsy, the "time window period" of epilepsy formation, and the best stage of drug intervention. Neuronal damage and immune inflammation are the basic characteristics of epileptogenesis, and immune inflammation participates in the whole process of epileptogenesis in children. Studies have found that inhibiting early inflammatory factors(IL-1, TNF-α, etc.) cannot prevent epileptogenesis. In recent years, the special position of high mobility protein B1(HMGB1) of late inflammatory factor in immune inflammation has been paid more and more attention. Functionally, HMGB1 has two different functions: intracellular gene regulation and extracellular pro-inflammation. Inhibiting the translocation of HMGB1 is the key to regulating its function. HMGB1 activates the downstream immune response through two classic transduction pathways: the HMGB1-RAGE axis and the HMGB1-TLRs axis. Traditional Chinese medicine mainly regulates the immune inflammatory response and interferes with the process of epilepsy through the HMGB1/TRL4/NF-κB pathway. This article reviews the sources, structures, functions, release forms, signal pathways, inhibitors and traditional Chinese medicine interventions of HMGB1 in order to provide a literature basis for traditional Chinese medicine intervention in HMGB1 and epileptogenesis.

Key words:

Epileptogenesis, HMGB1, Immune inflammation, TCM