Abstract:

Nephrotic syndrome is a clinical syndrome with a series of pathophysiological changes due to the increased permeability of glomerular filtration membrane to plasma protein and the loss of a large amount of plasma protein from urine. It is mainly characterized by massive proteinuria, hypoproteinemia, hyperlipidemia and edema.The disease can be relieved or even cured to a certain extent with hormone therapy, but there are still 20% of children with hormone resistance, which eventually progresses to end-stage renal disease. The changes of genes are very likely to lead to the occurrence of hormone-resistant nephrotic syndrome(SRNS). The study of SRNS-related genes and their polymorphisms is helpful to deepen the understanding of the disease and guide the clinical practice.

Key words:

Steroid resistant nephrotic syndrome, Genes, Podocyte, Immunization