Abstract: Objective:To systematically evaluate the efficacy and safety of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia.Methods:Randomized controlled trials of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia published in Chinese databases and English databases,including CNKI,Wanfang,VIP,CBM,Pubmed,Cochrane Library and Embase,were searched for by computer and the relevant grey literature was traced.Two researchers conducted literature screening and data extraction separately,and conducted quality evaluation of the included studies.The meta analysis and evidence quality evaluation were carried out using RevMan 5-4 software and GRADE system respectively.Results:A total of 16 studies were included,involving a total of 1 503 patients,752 patients in the experimental group and 751 patients in the control group.The results of meta analysis showed that the total effective rate,the antipyretic time,the disappearance time of cough,the disappearance time of sputum,the disappearance time of lung rales,CRP level,IL6 level and TNFα level were better by Xiaoer Feire Kechuan oral liquid than by conventional western medicine in the treatment of Mycoplasma pneumoniae pneumonia,and the incidence of adverse reactions was not increased.The grading results of GRADE evidence showed that the evidence of total effective rate,the disappearance time of sputum and the incidence of adverse reactions was the low grade;the evidence of antipyretic time,the disappearance time of cough and the disappearance time of lung rales,inflammatory indexes(CRP,IL6,TNFα） and lung function（FEV1,FEV1/FVC,MVV） was the very low grade.Conclusion:The therapeutic effect of Xiaoer Feire Kechuan oral liquid on Mycoplasma pneumoniae pneumonia in children is definite,and its safety is superior to conventional western medicine treatment.

Key words: Mycoplasma pneumoniae pneumonia, Xiaoer Feire Kechuan oral liquid, Meta analysis；GRADE evaluation, Child