基于数据挖掘分析现代名中医治疗抽动障碍的用药规律

doi:10.20274/j.cnki.issn.2025.04.002

Abstract

Abstract:

Objective To elucidate the common syndrome differentiation approaches and core prescription strategies of modern renowned traditional Chinese medicine (TCM) physicians in treating tic disorders using the TCM Inheritance Computing Platform（V3.5）. Methods Literature on renowned TCM physicians' treatment for tic disorders was collected from the China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and VIP Chinese Sci-Tech Journal Database from January 2000 to February 2025. Prescriptions for tic disorders were input into the TCM Inheritance Computing Platform（V3.5） for statistical analysis of frequency of medicinal use, association rules, cluster analysis, channel tropism of property and flavor, and efficacy. Results A total of 78 articles which met the inclusion criteria were collected, involving the experience of 61 renowned TCM physicians, and 104 prescriptions comprising 214 medicinal substances were included. Medicinal properties were predominantly cold and neutral; flavors were primarily sweet and bitter; channel tropism focused on the liver, lung, and spleen. The core combination was Baishao (Paeoniae Radix Alba), Gouteng (Uncariae Ramulus cum Uncis), and Gancao (Glycyrrhizae Radix et Rhizoma), supplemented by the core prescription of Tianma (Gastrodiae Rhizoma), Jiangcan (Bombyx Batryticatus), Chantui (Cicadae Periostracum), Shichangpu (Acori Tatarinowii Rhizoma), Fuling (Poria), Juhua (Chrysanthemi Flos), Muli (Ostreae Concha), Quanxie (Scorpio), and Chaihu (Bupleuri Radix). Conclusion The primary treatment principle of modern renowned TCM physicians for tic disorders is softening the liver and extinguishing wind, complemented by strategies such as calming the liver and purging fire, fortifying the spleen and resolving phlegm, and diffusing the lung and dispelling pathogens. Attention should be paid to syndrome differentiation and simultaneous treatment of root causes and symptoms, and the medicines used mainly include liver-calming and wind-extinguishing agents, tonics, and exterior-releasing substances.

Key words: Tic disorder, Renowned TCM physicians, Data mining, TCM Inheritance Computing Platform（V3.5）

CLC Number:

R277.7

Yuanhang SUN, Dongmei LI. Data mining-based analysis of medication patterns of modern renowned traditional Chinese medicine physicians for tic disorders[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 281-286.

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References 18

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序号	功效	频次	序号	功效	频次
1	平肝息风类	249	10	开窍类	36
2	补虚类	223	11	祛风湿类	35
3	解表类	187	12	消食类	17
4	清热类	173	13	化湿类	15
5	化痰止咳平喘类	92	14	收涩类	9
6	利水渗湿类	59	15	泻下类	8
7	活血化瘀类	58	16	温里类	3
8	理气类	55	17	驱虫类	2
9	安神类	42

序号	四气	频次	序号	五味	频次
1	寒	540	1	甘	587
2	平	324	2	苦	551
3	温	300	3	辛	476
4	凉	96	4	咸	151
5	热	3	5	酸	128

序号	关联规则	置信度	序号	关联规则	置信度
1	牡蛎→白芍	0.88	17	天麻→白芍	0.62
2	菊花→钩藤	0.85	18	全蝎→白芍	0.62
3	菊花→白芍	0.85	19	石菖蒲→钩藤	0.61
4	白芍,天麻→钩藤	0.80	20	蝉蜕→白芍	0.61
5	柴胡→白芍	0.77	21	白芍,钩藤→甘草	0.60
6	蝉蜕→僵蚕	0.74	22	白芍→钩藤	0.60
7	钩藤,甘草→白芍	0.73	23	白芍→甘草	0.58
8	钩藤,天麻→白芍	0.71	24	甘草→钩藤	0.58
9	天麻→钩藤	0.70	25	茯苓→钩藤	0.57
10	钩藤→白芍	0.69	26	钩藤→甘草	0.57
11	甘草→白芍	0.68	27	僵蚕→钩藤	0.55
12	石菖蒲→白芍	0.67	28	天麻→甘草	0.55
13	僵蚕→白芍	0.64	29	茯苓→甘草	0.54
14	僵蚕→蝉蜕	0.64	30	蝉蜕→钩藤	0.53
15	茯苓→白芍	0.62	31	白芍,钩藤→天麻	0.50
16	白芍,甘草→钩藤	0.62	32	天麻→僵蚕	0.50

序号	药物组合	频数
1	白芍,钩藤,甘草,天麻，僵蚕,石菖蒲	50
2	白芍,钩藤,甘草,生地黄,牡蛎,茯苓	21
3	白芍,钩藤,甘草,白术,茯苓,木瓜	18
4	白芍,钩藤,甘草,蝉蜕,半夏,僵蚕	15

Data mining-based analysis of medication patterns of modern renowned traditional Chinese medicine physicians for tic disorders

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序号	药物	频次	序号	药物	频次
1	白芍	69	16	葛根	20
2	钩藤	58	17	龙骨	18
3	甘草	57	18	远志	18
4	僵蚕	44	19	木瓜	16
5	天麻	40	20	桔梗	16
6	蝉蜕	38	21	生地黄	15
7	茯苓	37	22	白术	13
8	石菖蒲	36	23	珍珠母	13
9	全蝎	32	24	石决明	12
10	半夏	32	25	黄芩	12
11	菊花	26	26	防风	12
12	柴胡	26	27	辛夷	12
13	牡蛎	24	28	栀子	12
14	郁金	24	29	枳壳	12
15	陈皮	23	30	连翘	11

序号	四气	频次	序号	五味	频次
1	寒	540	1	甘	587
2	平	324	2	苦	551
3	温	300	3	辛	476
4	凉	96	4	咸	151
5	热	3	5	酸	128

序号	药物组合	频次	序号	药物组合	频次
1	白芍,钩藤	40	13	钩藤,石菖蒲	22
2	白芍,甘草	39	14	钩藤,菊花	22
3	钩藤,甘草	33	15	白芍,菊花	22
4	白芍,僵蚕	28	16	甘草,天麻	22
5	钩藤,天麻	28	17	白芍,牡蛎	21
6	僵蚕,蝉蜕	28	18	钩藤,茯苓	21
7	白芍,天麻	25	19	白芍,钩藤,天麻	20
8	钩藤,僵蚕	24	20	白芍,全蝎	20
9	白芍,钩藤,甘草	24	21	甘草,茯苓	20
10	白芍,石菖蒲	24	22	白芍,柴胡	20
11	白芍,茯苓	23	23	僵蚕,天麻	20
12	白芍,蝉蜕	23	24	钩藤,蝉蜕	20

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序号	四气	频次	序号	五味	频次
1	寒	540	1	甘	587
2	平	324	2	苦	551
3	温	300	3	辛	476
4	凉	96	4	咸	151
5	热	3	5	酸	128

序号	四气	频次	序号	五味	频次
1	寒	540	1	甘	587
2	平	324	2	苦	551
3	温	300	3	辛	476
4	凉	96	4	咸	151
5	热	3	5	酸	128