赛庚啶在儿童消化系统疾病中的应用

doi:10.20274/j.cnki.issn.2025.04.005

Abstract

Abstract:

Cyproheptadine, a multi-receptor antagonist with antihistaminic, anticholinergic, and anti-serotonergic properties, has recently demonstrated favorable efficacy and safety profiles in the treatment of functional gastrointestinal disorders (FGID) in children. This article mainly elaborates on the mechanisms of action, clinical application regimens, and therapeutic evaluations of cyproheptadine in conditions such as functional dyspepsia (FD), abdominal migraine (AM), cyclic vomiting syndrome (CVS), and anorexia nervosa, thereby providing a reference for its clinical use in the treatment of pediatric digestive diseases. Further prospective studies are warranted in the future to establish clear guidelines for its administration in order to promote its rational and standardized application in pediatric diseases.

Key words: Digestive disorders, Cyproheptadine, Child

CLC Number:

R725.7

Ziying LI, Yuesheng WANG, Xiaoqin LI. Application of cyproheptadine in digestive disorders in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 298-301.

References 40

[1]	Huang Y, Tan SY, Parikh P, et al. Prevalence of functional gastrointestinal disorders in infants and young children in China[J]. BMC Pediatr, 2021, 21(1): 131.
[2]	Steutel NF, Zeevenhooven J, Scarpato E, et al. Prevalence of functional gastrointestinal disorders in European infants and toddlers[J]. J Pediatr, 2020, 221: 107-114.
[3]	Vernon-Roberts A, Alexander I, Day AS. Systematic review of pediatric functional gastrointestinal disorders(Rome Ⅳ criteria)[J]. J Clin Med, 2021, 10(21): 5087.
[4]	邹毅, 张慧华, 刘波, 等. 儿科消化门诊功能性胃肠疾病诊疗现状: 一项单中心的临床报道[J]. 中国实用儿科杂志, 2021, 36(8): 632-636.
[5]	Di Nardo G, Barbara G, Borrelli O, et al. Italian guidelines for the management of irritable bowel syndrome in children and adolescents: joint Consensus from the Italian Societies of: gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM)[J]. Ital J Pediatr, 2024, 50(1): 51.
[6]	张薇, 王宝西. 儿童功能性胃肠病诊治现状[J]. 中国小儿急救医学, 2022, 29(2): 81-85.
[7]	Powers PS, Santana C. Available pharmacological treatments for anorexia nervosa[J]. Expert Opin Pharmacother, 2004, 5(11): 2287-2292.
[8]	Homnick DN, Marks JH, Hare KL, et al. Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis[J]. Pediatr Pulmonol, 2005, 40(3): 251-256.
[9]	Rodriguez L, Diaz J, Nurko S. Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children[J]. J Pediatr, 2013, 163(1): 261-267.
[10]	Merhar SL, Pentiuk SP, Mukkada VA, et al. A retrospective review of cyproheptadine for feeding intolerance in children less than three years of age: effects and side effects[J]. Acta Paediatr, 2016, 105(8): 967-970.
[11]	Bertrand V, Massy N, Vegas N, et al. Safety of cyproheptadine, an orexigenic drug. analysis of the French national pharmacovigilance data-base and systematic review[J]. Front Pediatr, 2021, 9: 712413.
[12]	中华医学会儿科学分会消化学组, 中国中药协会儿童健康与药物研究专业委员会消化学组, 中华儿科杂志编辑委员会, 等. 中国儿童功能性消化不良诊断和治疗共识(2022版)[J]. 中华儿科杂志, 2022, 60(8): 751-755.
[13]	Shava U, Srivastava A, Mathias A, et al. Functional dyspepsia in children: a study of pathophysiological factors[J]. J Gastroenterol Hepatol, 2021, 36(3): 680-686.
[14]	O’Mahony SM, Clarke G, Borre YE, et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis[J]. Behav Brain Res, 2015, 277: 32-48.
[15]	中国医师协会神经内科医师分会, 中国研究型医院学会头痛与感觉障碍专业委员会. 中国偏头痛诊治指南(2022版)[J]. 中国疼痛医学杂志, 2022, 28(12): 881-898.
[16]	Mortimer MJ, Kay J, Jaron A. Clinical epidemiology of childhood abdominal migraine in an urban general practice[J]. Dev Med Child Neurol, 1993, 35(3): 243-248.
[17]	耿岚岚(译,刘明南(译,龙高(译,等. 儿童功能性胃肠病罗马Ⅳ标准[J]. 中华儿科杂志,2017,55(1):4-14.
[18]	Cheema S, Matharu M. Abdominal migraine and cyclical vomiting syndrome[J]. Handb Clin Neurol, 2023, 198: 209-219.
[19]	Papetti L, Ursitti F, Moavero R, et al. Prophylactic treatment of pediatric migraine: is there anything new in the last decade[J]? Front Neurol, 2019, 10: 771.
[20]	Lewis DW, Diamond S, Scott D, et al. Prophylactic treatment of pediatric migraine[J]. Headache, 2004, 44(3): 230-237.
[21]	Kacperski J, Hershey AD. Preventive drugs in childhood and adolescent migraine[J]. Curr Pain Headache Rep, 2014, 18(6): 422.
[22]	Graudins A, Stearman A, Chan B. Treatment of the serotonin syndrome with cyproheptadine[J]. J Emerg Med, 1998, 16(4): 615-619.
[23]	郭姝, 吴捷. 儿童周期性呕吐综合征的治疗策略[J]. 中国小儿急救医学, 2022, 29(2): 95-98.
[24]	Fitzpatrick E, Bourke B, Drumm B, et al. The incidence of cyclic vomiting syndrome in children: population-based study[J]. Am J Gastroenterol, 2008, 103(4): 991-995.
[25]	Venkatesan T, Prieto T, Barboi A, et al. Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study[J]. Neurogastroenterol Motil, 2010, 22(12): 1303-1307.
[26]	Hasler WL, Levinthal DJ, Tarbell SE, et al. Cyclic vomiting syndrome: pathophysiology, comorbidities, and future research directions[J]. Neurogastroenterol Motil, 2019, 31(): e13607.
[27]	McAbee GN, Morse AM, Cook W, et al. Neurological etiologies and pathophysiology of cyclic vomiting syndrome[J]. Pediatr Neurol, 2020, 106: 4-9.
[28]	Li BUK, Lefevre F, Chelimsky GG, et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome[J]. J Pediatr Gastroenterol Nutr, 2008, 47(3): 379-393.
[29]	唐硕, 游洁玉, 欧阳文献, 等. 小儿再发性呕吐综合征的临床疗效观察[J]. 中国当代儿科杂志, 2010, 12(12): 993-994.
[30]	罗艳红, 游洁玉. 赛庚啶、胞二磷胆碱治疗小儿周期性呕吐综合征疗效观察[J]. 临床儿科杂志, 2008, 26(10): 847-849.
[31]	Badihian N, Saneian H, Badihian S, et al. Prophylactic therapy of cyclic vomiting syndrome in children: comparison of amitriptyline and cyproheptadine: a randomized clinical trial[J]. Am J Gastroenterol, 2018, 113(1): 135-140.
[32]	Thavamani A, Umapathi KK, Velayuthan S, et al. Burden of psychiatric disorders in patients with cyclic vomiting syndrome - Need for aggressive screening and early intervention[J]. Dig Liver Dis, 2022, 54(2): 287-289.
[33]	Kovacic K, Sood M, Venkatesan T. Cyclic vomiting syndrome in children and adults: what is new in 2018[J]? Curr Gastroenterol Rep, 2018, 20(10): 46.
[34]	Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition[J]. Eur J Oncol Nurs, 2005, 9(): S51-63.
[35]	Chakrabarty AS, Pillai RV, Anand BK, et al. Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres[J]. Brain Res, 1967, 6(3): 561-569.
[36]	Bisschops R, Karamanolis G, Arts J, et al. Relationship between symptoms and ingestion of a meal in functional dyspepsia[J]. Gut, 2008, 57(11): 1495-1503.
[37]	Najib K, Moghtaderi M, Karamizadeh Z, et al. Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial[J]. Iran J Pediatr, 2014, 24(6): 753-758.
[38]	Harrison ME, Norris ML, Robinson A, et al. Use of cyproheptadine to stimulate appetite and body weight gain: a systematic review[J]. Appetite, 2019, 137: 62-72.
[39]	Sant’Anna AMGA, Hammes PS, Porporino M, et al. Use of cyproheptadine in young children with feeding difficulties and poor growth in a pediatric feeding program[J]. J Pediatr Gastroenterol Nutr, 2014, 59(5): 674-678.
[40]	Badr B, Naguy A. Cyproheptadine : a psychopharmacological treasure trove[J]? CNS Spectr, 2022, 27(5): 533-535.

Application of cyproheptadine in digestive disorders in children

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 40

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Mingqing LUO, Shuxin SUN, Jing LI. Clinical research advances in auricular acupoint therapy for pediatric tic disorders [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 277-280.
[2]	Qingmei ZHANG, Baiye XU, Haidao WANG, Zhen CHEN, Tingting CHEN. Investigation and analysis of sleep quality in children with tic disorders [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 287-291.
[3]	Lü GAO, Chi LIU, Zhengyu YAO, Yijue JING, Liping WU, Zhenggang SHI. Exploring the anti-epileptic mechanism of Pingxian granules and its split formula based on neuronal apoptosis [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 292-297.
[4]	Xingqian YI, Jing Ying NG, Zhiyi XIONG, Xiaofan CHEN, Ying LIU, Xiaoyan LI, Li WANG. Analysis of intestinal microbiome characteristics of children with autism in China based on literature research [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 302-312.
[5]	Zengquan ZHONG, Xue JIANG, Shuangquan SUN, Yiming LI, Wei LI, Xin ZHANG, Hong LI, Zhihai LYU. Efficacy and follow-up of ultrasound-guided botulinum toxin type A injection for lower limb spasticity in cerebral palsy [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 313-319.
[6]	Li ZHANG, Yanfei YANG, Yanfen WANG. Clinical features and prognostic analysis of 21 cases of histiocytic necrotizing lymphadenitis in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 324-329.
[7]	Ye LI, Yuhuan WAN, Zhuo LI. Construction and validation of risk prediction model for postoperative malnutrition in children with intracranial space-occupying lesions [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 330-335.
[8]	Bowen XU, Bin XIE, Xuefeng WANG. Professor Wang Xuefeng's experience in treating attention-deficit hyperactivity disorder based on liver and kidney [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 336-339.
[9]	Guiwen LI, Shangan SI, Guiju ZHANG. Treatment for childhood obesity combined with precocious puberty based on entropy disease theory [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 340-345.
[10]	Yanli CUI, Li XU. Treatment for pediatric Henoch-Schönlein purpura based on the theory of "Xuanfu-Qixue-Luomai" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 346-350.
[11]	Hangbo LIN, Liping SUN. An analysis of the experience in the treatment of pediatric chronic urticaria based on the theory of lung heat [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 351-354.
[12]	Yuechen SUN, Ru XU, Weiwei LIU, Yadong LI. Differential treatment by stages for mycoplasma pneumonia in children based on the theory of "Xuanfu-Qiye-Luomai" of the lung [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 355-358.
[13]	Weizhuo LIU, Liping SUN. Three-phase treatment for children with allergic rhinitis with wind-cold syndrome of the lung meridian based on the "Ying-Wei theory" combined with syndrome differentiation of viscera [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(4): 359-362.
[14]	. Clinical practice guidelines for integrative Chinese and western medicine in children with enuresis (2025) [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 185-198.
[15]	Yuanjun LU, Na CHEN, Yang YANG, Man CHENG, Duojian LI, Qiuyue LI, Zhu CHEN. Differentiated treatment for central precocious puberty based on the five viscera and the theory of "Tiangui" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 203-207.