Abstract:
Objective：To explore the clinical significance of urine MA，blood beta2-MG，alpha1-MG，Cys-C in pediatric early renal damage.
Methods：Totally 500 cases of children with acute infection in Pediatrics Department of Baotou Eighth Hospital from November 2014 to October 2015 were included. Urine MA，blood beta2-MG，alpha1-MG，Cys-C，BUN，and Cr were detected.Those with increase in any one item were selected as kidney dysfunction observation group(108 cases).At the same time 70 healthy pediatric patients who came for regular check-ups at the OPD were selected as control group.Explore the clinical significance of urine MA，blood beta2MG，alpha1-MG，and Cys-C in different types of infectious early renal damage.
Results：In observation group，urine MA，blood beta2-MG，alpha1-MG and Cys-C were all significantly higher than that of control group(P＜0.05)；BUN and Cr had no statistically significant difference between the two groups(P＞0.05).Blood alpha 1-MG in the infection group had the lowest detection rate. In virus infection group，the detection rate of urine MA，blood beta2-MG and Cys-C was different，the difference being statistically significant(P＜0.05)，in which the detection rate of blood beta2-MG was the highest. Cys-C's detection rate had no statistical difference in different infection groups.
ConclusionThis study suggests the blood beta2-MG is the most sensitive in diagnosis of virus infection with early renal damage.The increase of Cys-C is not limited by the type of infection，and is a good indicator of various types of infectious renal impairment.

Key words: Early renal damage, Infectious, Urine MA, Beta2-MG, Alpha1-MG, Cys-C, Children