ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2013, Vol. 5 ›› Issue (1): 5-8.doi: 10.3969/j.issn.1674-3865.2013.01.002

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The experimental study of Yiqi Guben capsule in adjusting the splenic lymphocyte proliferation of lungQi deficiency mice

SUN Yingying,SUN Liping.   

  1. The Graduate School of Changchun University of Traditional Chinese Medicine,Changchun 130117,China
  • Online:2013-02-25 Published:2019-04-25

Abstract:
Objective:To discuss the Yiqi Guben capsule role in regulating the splenic lymphocyte proliferation of lungQi deficiency mice.
Methods:Totally 96 mice (male and female in half) were equally divided into 6 groups: normal control group, model group, Yiqi Guben capsules highdose group, middledose group and lowdose group, control group of Yupingfeng powder. Apart from the normal group, the mice in the rest of each group were made into lungQi deficiency syndrome models by adopting improved smoked method; tested drugs were given by intragastric administration for five weeks; XTT method was taken to assay the proliferation of splenic lymphocyte stimulated by the LSP or ConA.
Results:After lungQi deficiency modeling,the function of the splenic B and T lymphocyte proliferation was significantly lower than the normal control group (P<0.001);after the tested drugs were given by intragastric administration, the function of splenic B and T lymphocyte proliferation was significantly increased; compared  with the model group, the splenic lymphocyte proliferation function of control group, of Yupingfeng powder group, of Yiqi Guben capsule highdose group and middledose group was significantly increased(P<0.05),and the increase of Yiqi Guben capsule highdose group was the most significant.
Conclusions:Yiqi Guben capsule can improve the lymphocyte proliferation activity of lungQi deficiency mice,thereby regulate the immune function.