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Diagnosis and treatment guideline for functional dyspepsia in children with the integrated traditional Chinese and western medicine WANG Xuefeng, WU Jie, GONG Sitang, XIONG Lei, JIANG Mizu, WANG Baoxi, XU Hua, PENG Yu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 461-468.   DOI: 10.3969/j.issn.1674-3865.2024.06.001 Abstract （250）      PDF（pc） （1049KB）（335）       Knowledge map    Save Functional dyspepsia,as one of the most common functional diseases of upper digestive tract,seriously affects the quality of life and growth and development of children in China.Due to the changing definition and symptom spectrum of functional dyspepsia in children,its diagnosis and treatment are controversial.In order to standardize the diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine,and effectively solve the clinical problems in the diagnosis and treatment of children with functional dyspepsia,this guideline is formulated to guide the standardized diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine. Related Articles | Metrics

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Treatment experience of functional dyspepsia in children by the "Spleen regulation and mediation method" of the Huang's Pediatric School in central Guizhou Province PENG Yu, WU Min, LIU Qiyan, CHEN Zhu, SUN Haipeng, YANG Jianhui, LENG Li, PANG Ping, YE Qian Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 468-472.   DOI: 10.3969/j.issn.1674-3865.2024.06.002 Abstract （137）      PDF（pc） （996KB）（262）       Knowledge map    Save Functional dyspepsia (FD) is a common digestive disorder among children. Clinically, it is primarily characterized by postprandial fullness, early satiety, upper abdominal pain, or a burning sensation in the upper abdomen. It may also be accompanied by symptoms such as belching, acid regurgitation, nausea, vomiting, poor appetite, and abdominal distension, presenting a wide range of manifestations. FD is prone to recurrence and has a relatively prolonged course. According to its main symptoms, it is categorized into conditions such as "abdominal pain," "abdominal distension," "epigastric fullness," and "vomiting" for syndrome differentiation and treatment in traditional Chinese medicine (TCM). The etiology of FD is often attributed to improper diet or post-illness disorders, with the pathogenesis being dysfunction in the ascending and descending mechanisms of the spleen and stomach qi. In Huang's Pediatric School of central Guizhou Province, it is believed that whether it is deficiency or excess, "the failure of the spleen to transport and regulate" is the key to the pathogenesis of pediatric FD, and it is also the core pathogenesis of the symptoms such as "epigastric fullness, distension, and pain." In clinical practice, the severity of symptoms, duration of the disease, and characteristics of the nasal root and eyelids are assessed to determine the nature of the syndrome, including cold, heat, deficiency, and excess. Thus, the "Spleen regulation and mediation method" is established, and the "Spleen-regulating and Fullness-relieving powder" is used for syndrome-differentiated treatment, aiming to rapidly restore the "spleen-transporting" function in children with FD and achieve the state of the spleen "regulating the qi of the four viscera," which provides a clinical reference for TCM treatment of pediatric FD. Related Articles | Metrics

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Analysis of the experience of the Diannan School of Pediatrics in differentiation and treatment of pediatric functional dyspepsia based on the theory of "yang is exposed to wind and yin is exposed to dampness" HE Xiying, XIONG Lei, CAO Ting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 473-476.   DOI: 10.3969/j.issn.1674-3865.2024.06.003 Abstract （127）      PDF（pc） （982KB）（145）       Knowledge map    Save Functional dyspepsia (FD) is a common gastrointestinal disorder in pediatrics,closely associated with poor diet and lifestyle habits.The main clinical manifestations include upper abdominal fullness,pain,anorexia,belching,nausea,vomiting,and acid regurgitation.If not intervened in time,this disease may lead to growth retardation and malnutrition.In western medicine, this disease is often managed by symptomatic therapy,such as using prokinetic and antisecretory drugs to improve children's appetite and relieve abdominal distension and abdominal pain,but it is easy to recur.Numerous studies have proved that traditional Chinese medicine (TCM) is safe and effective in improving anorexia,belching,abdominal distension,abdominal pain,vomiting,etc.,and can be used alone to treat children with FD.Prof.Xiong Lei,a representative figure of the Diannan School of Pediatrics,believes that the origin of this disease is always in the spleen and stomach:it may be because "yang is exposed to wind" and the pathogenic qi invades the stomach,blocking the flow of qi in the middle jiao,or it may be because "yin is exposed to dampness" and the dampness is trapped in the spleen,resulting in the dysfunction of spleen,which leads to FD.Based on the theory of "yang is exposed to wind and yin is exposed to dampness",prof.Xiong believes that when the spleen and stomach are trapped,non-aromatic TCM cannot activate them.In clinical practice,the use of TCM formulas with aromatic characteristics can activate the spleen and eliminate dampness,regulate qi of the middle jiao,and restore the function of the spleen and stomach,thereby having significant therapeutic effects in the treatment of FD. Related Articles | Metrics

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Exploring the pathogenesis of pediatric functional dyspepsia based on the theory of "spleen deficiency as the root" WANG Na, LIU Shiyu, LIU Jie, YU Jian, XIONG Lei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 477-481.   DOI: 10.3969/j.issn.1674-3865.2024.06.004 Abstract （125）      PDF（pc） （1035KB）（140）       Knowledge map    Save Functional dyspepsia(FD) is a common chronic gastrointestinal disorder in children,characterized by symptoms such as upper abdominal discomfort,abdominal distension,poor appetite,and acid regurgitation.The pathogenesis of FD is complex,involving multiple factors such as gastrointestinal motility disorders,visceral hypersensitivity,and brain-gut axis dysfunction.In traditional Chinese medicine (TCM),it is believed that the theory of "spleen deficiency as the root" is the core pathological mechanism.Specifically,spleen deficiency impairs the normal flow of qi,leading to the accumulation of dampness and stagnation,which brings about gastrointestinal motility issues and visceral hypersensitivity.Furthermore,spleen dysfunction weakens qi and hinders digestive absorption and blood production,worsening gut microbiota imbalances and disrupting brain-gut axis regulation.The TCM treatment strategy for FD involves four key approaches:strengthening the spleen,regulating spleen qi,activating spleen function,and balancing qi flow.Strengthening the spleen and eliminating dampness enhances gastrointestinal motility and removes stagnation.Regulating spleen qi improves digestion and relieves food retention.Activating spleen function restores healthy digestion and absorption.Balancing qi flow ensures smooth coordination of qi ascending and descending to relieve stagnation.These TCM methods align closely with modern medical strategies of regulating gastrointestinal motility,reducing visceral hypersensitivity,and balancing brain-gut axis.This study systematically explores the pathogenesis of FD and the treatment strategy of integrating TCM with modern medicine from the perspective of "spleen deficiency as the root".It highlights the intricate interactions among spleen function,the brain-gut axis,and gut microbiota.This research provides theoretical foundation and guidance for the treatment of children with FD. Related Articles | Metrics

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Paying attention to the standardized diagnosis and treatment for children with short stature LUO Xiaoping, WU Wei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 369-371.   DOI: 10.3969/j.issn.1674-3865.2024.05.001 Abstract （262）      PDF（pc） （1010KB）（230）       Knowledge map    Save Short stature has a significant impact on the physical and mental health of children, and it is a common disease in the endocrine department of pediatrics. Due to the rapid changes in children's growth and development and the complex etiology of short stature, there have always been such issues as missed diagnoses, misdiagnoses and insufficient intervention or overtreatment. This necessitates the strengthening of standardized diagnosis and treatment. This article discusses the challenges faced in the clinical diagnosis and treatment of children with short stature, especially emphasizing two aspects: one is to find out the etiology and make precise diagnosis, and the other is to perform individualized treatment strictly based on the indications. Meanwhile, the future direction of diagnosis and treatment of short stature is prospected, and suggestions are put forward for further standardization of diagnosis and treatment behavior of short stature, in order to provide useful reference for clinicians and policy makers. Related Articles | Metrics

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Expert consensus on traditional Chinese medicine intervention program for atopic dermatitis in children Zhao Yun, Ma Chunyan, Deng Dan, Wu Liqun, Zhang Huimin, Zhao Xia, Ye Qingyan, Zhu Shengguo, Yao Ting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (3): 185-190.   DOI: 10.3969/j.issn.1674-3865.2024.03.001 Abstract （235）      PDF（pc） （851KB）（144）       Knowledge map    Save Atopic dermatitis in children is a common skin disease in infants and young children under the age of 3.Its recurrent itching and skin lesions affect the quality of life of the children.In order to further strengthen the clinical application and promotion of traditional Chinese medicine intervention in children with atopic dermatitis,the Pediatric Committee of Shanghai Association of Traditional Chinese Medicine and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine have taken the lead in formulating this consensus,aiming to provide guidance for practitioners in traditional Chinese medicine pediatrics and better assist children. Related Articles | Metrics

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Guidelines for the diagnosis and treatment of influenza in children with integrated traditional Chinese and western medicine WANG Xuefeng, WANG Lining, DENG Li, LIU Hanmin, SHANG Yunxiao, ZHANG Baoqing, ZHAO Shunying Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (2): 93-101.   DOI: 10.3969/j.issn.1674-3865.2024.02.001 Abstract （478）      PDF（pc） （1052KB）（457）       Knowledge map    Save Children are the high incidence population of influenza and the high risk population of severe cases.Early intervention of influenza,especially the intervention with traditional Chinese and western medicine in the mild stage,is of great significance to the prognosis of the disease.Based on the development process of literature retrieval and evaluation,expert interview,group discussion,expert demonstration meeting and public consultation,the guidelines for the diagnosis and treatment of influenza in children with integrated traditional Chinese and western medicine are formed.This version of the guidelines includes the scope of application,normative reference documents,terms and definitions,diagnosis and treatment,aiming to provide an important reference for the clinical practice,diagnosis and treatment norms and quality evaluation of the treatment with integrated traditional Chinese and western medicine for children with influenza. Related Articles | Metrics

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Expert consensus on external treatment for tic disorder in children with traditional Chinese medicine(2024) Wang Xuefeng, Han Xinmin, Sun Kexing, Jiang Yonghong, Rong Ping Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (1): 1-7.   DOI: 10.3969/j.issn.1674-3865.2024.01.001 Abstract （392）      PDF（pc） （1087KB）（336）       Knowledge map    Save Tic disorder is one of the most common neuropsychiatric diseases in children in clinical practice, which does great harm to children's physical and mental health. External therapy with traditional Chinese medicine, represented by acupuncture and massage, has some special advantages in the treatment of tic disorder in children, but it needs to be further standardized. This consensus covers the terms and definitions of tic disorder in children, the diagnosis, etiology and pathogenesis, syndrome differentiation and technological standards of external therapy with traditional Chinese medicine, and summarizes the modern medical experience and the advances in evidence-based medicine of this disease. This consensus highlights the clinical practicality and reflects the latest research progress, which helps to improve the level of clinical standardization of external therapy for tic disorder in children with traditional Chinese medicine. Related Articles | Metrics

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Expert consensus on clinical diagnosis and treatment of simple obesity in Chinese children with integrated traditional Chinese and western medicine He Jingwei, Pei Zhou, Qian Tian, Zhou Yiyao, Luo Feihong, Yu Jian Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (1): 1-7.   DOI: 10.3969/j.issn.1674-3865.2023.01.001 Abstract （323）      PDF（pc） （889KB）（195）       Knowledge map    Save Obesity is an important risk factor for chronic diseases such as hypertension，hyperlipidemia and type 2 diabetes in children. Childhood obesity in China tends to be at young age and with rapid growth. There is little research on childhood obesity in traditional Chinese medicine，and there is no unified standard for syndrome differentiation and classification. There is still no effective prevention and treatment protocols for childhood obesity. It is urgent to formulate an effective consensus and protocols for clinical diagnosis and treatment of childhood obesity based on Chinese medicine and western medicine. This consensus has been revised repeatedly based on the latest guidelines，consensus and research progress of Chinese and western medicine at home and abroad and combined with the clinical practice and experience of childhood obesity in China，aiming to provide clinical reference decisions for the diagnosis and treatment of childhood obesity，so as to improve the overall control level of childhood obesity. Related Articles | Metrics

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Research status of the influence of prone position on sleep and organ functions in premature infants FU Caiyu, WANG Aiqiong, SA Rina Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 305-309.   DOI: 10.3969/j.issn.1674-3865.2023.04.006 Abstract （110）      PDF（pc） （860KB）（14）       Knowledge map    Save The sleep development of premature infants is a highly dynamic process, which is closely related to the function of heart, lung and brain as well as growth and development. Researches on prone position(PP) has attracted increasing attention in terms of its effects on pulmonary oxygenation, cardiopulmonary stability, cerebral blood perfusion, brain function, and digestion in preterm infants, which are highly relevant to changes in body position during PP and its effects on sleep. Although much research progress has been made in the effects of PP on sleep development and organ function of premature infants, there are still some controversial issues that need further research. This paper will start from the sleep and organ development characteristics of premature infants, and focus on the effects of PP on sleep, heart, lung, brain and digestion of premature infants. This paper mainly reviews the effects of PP on sleep of premature infants and the effects of PP on the relationship between sleep state and organ function of premature infants. Related Articles | Metrics

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Research progress in autoimmune encephalitis in children TANG Yongzai, QIAO Pei, WU Mei, WANG Chunyan, DONG Yan Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 309-313.   DOI: 10.3969/j.issn.1674-3865.2023.04.007 Abstract （141）      PDF（pc） （879KB）（70）       Knowledge map    Save In recent years, autoimmune encephalitis has been paid more and more attention to in central immune diseases. In 1960s, some scholars have found that patients with marginal damage were often complicated with tumor lesions of other systems. With the research deepened, paraneoplastic, non-paraneoplastic and infectious types have also been found. The pathogenesis of autoimmune encephalitis is unknown. The most common clinical classification of autoimmune encephalitis is based on different types of antireceptors, and different classifications have different clinical manifestations. For different clinical symptoms, the treatment for autoimmune encephalitis includes symptomatic treatment and immunotherapy. This article will summarize the above aspects in order to provide some reference for clinicians' understanding of the disease. Related Articles | Metrics

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Research progress in the genetics of febrile seizures in children JIANG Yanli, YAN Lulu, XIE Min, ZHUANG Danyan, LI Haibo Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 314-318.   DOI: 10.3969/j.issn.1674-3865.2023.04.008 Abstract （100）      PDF（pc） （890KB）（84）       Knowledge map    Save Febrile seizures（FS） is one of the most common diseases in infancy and early childhood, and some children with FS progress to epilepsy in the later stage of the disease. At present, the pathogenesis of FS is not clear. In recent years, studies have shown that FS has a significant familial genetic tendency, and their pathogenesis is related to mutations in sodium channel genes, potassium channel genes, chloride channel genes, cytokine genes, proline-rich transmembrane protein 2 gene, and synaptic fusion protein 1B gene.  Related Articles | Metrics

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Professor Ma Rong's experience in the treatment of children with tic disorder through the "Three-step syndrome differention" mode NIE Lianghui, MA Rong, RONG Ping, ZHANG Xilian Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (5): 369-373.   DOI: 10.3969/j.issn.1674-3865.2023.05.001 Abstract （265）      PDF（pc） （954KB）（301）       Knowledge map    Save The etiology of tic disorder in children is complicated, the symptoms are various, and it is easy to be affected by social environment, so the treatment is challenging. Based on many years of clinical experience and through the combination with the theory of TCM and the characteristics of the disease, Professor Ma Rong first established the "Three-stem syndrome differentiation" mode for the treatment of children with tic disorder. The main content is as follows. The first step is disease differentiation, which is to take the root cause as the main point and make clear diagnosis. The second step is syndrome differentiation, which is to classify the syndrome and give prescription based on rules. The third step is symptom differentiation, which is to be clear with the symptoms and make modification. The differentiation of the disease is mainly the diagnosis and differential diagnosis of Chinese and western medicine, and the clinical descriptive diagnosis is used to exclude the symptoms of eye tutting and nose shrugs caused by allergic conjunctivitis and allergic rhinitis. The syndrome differentiation is mainly based on the TCM syndromes of the children, and the main treatment principle is to calm the wind and stop movement. The patients with exogenous wind evil were the syndrome of exogenous wind and were treated with Yinqiao powder with modification. The patients with both beating other people and destroying objects and obscene language were the syndrome of phlegm-fire disturbing the heart, and were treated with Ditan decoction. The patients with irritability were qi stagnation turning into fire, and Xieqing pills were used with modification. The patients who were sensitive with too many doubts and much anxiety were qi stagnation activating wind, and they were treated with Chaihu Guizhi Longgu Muli decoction with modification. Symptom differentiation is based on disease differentiation and syndrome differentiation, and the drugs for treatment are selected according to different parts of twitches and different vocal manifestations, which plays the role of guiding meridians and directly eliminating symptoms. The "Three-step syndrome differentiation" mode has clear diagnosis and treatment plan, and can be adjusted flexibly according to disease-syndrome-symptom of the patients, which is effective in clinical practice. Related Articles | Metrics

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A randomized controlled clinical study on the treatment of moderate tic disorder with Qufeng Zhidong plaster GAO Yuan, WU Min, JIANG Keyu, ZHANG Xin, ZHAO Xin Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (5): 388-392.   DOI: 10.3969/j.issn.1674-3865.2023.05.005 Abstract （131）      PDF（pc） （924KB）（22）       Knowledge map    Save Objective To evaluate the clinical effect of Qufeng Zhidong plaster in the treatment of moderate tic disorder. Methods From January 2021 to December 2022, 140 children were evaluated as moderate tic disorder in the tic disorder specialist clinic and the traditional Chinese medicine pediatric clinic of Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and were randomly divided into the observation group and the control group, with 70 cases in each group. All patients were treated with Qufeng Zhidong formula. On this basis, Qufeng Zhidong plaster was used in the observation group and blank simulated plaster was used in the control group. After 3 months of treatment, the clinical efficacy and TCM syndrome score of the two groups were evaluated. Results Five cases were removed from the observation group and 8 cases were removed from the control group. At 12 weeks after treatment, there was no statistical difference in the incidence of adverse reactions between the observation group and control group (P>0.05), and the total clinical effective rate of the observation group was 95.38% (62/65), which was higher than that of the control group (83.87%,52/62), and the difference was statistically significant (P<0.05). The YGTSS score of children with tic disorder was improved by both treatment methods. The treatment of Qufeng Zhidong plaster plus Qufeng Zhidong formula was better than that of simulated plaster plus Qufeng Zhidong formula, and the difference was statistically significant (P<0.05). After 12 weeks of treatment, the total efficacy score of the observation group was lower than that of the control group, and the efficacy index score was higher than that of the control group, the difference being with statistical significance (P<0.05). The TCM syndrome score of the observation group was lower than that of the control group at 8 weeks and 12 weeks after treatment, and the difference was statistically significant(P<0.05). Conclusion Qufeng Zhidong plaster combined with Chinese medicine is effective in the treatment of moderate tic disorder, and can significantly improve the clinical symptoms and TCM syndromes of patients. Related Articles | Metrics

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Observation on the clinical therapeutic effect of traditional Chinese medicine combined with acupuncture on tic disorders in children LIU Quanhui, FU Qianfang, ZHANG Xilian, RONG Ping, MA Rong Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (5): 393-397.   DOI: 10.3969/j.issn.1674-3865.2023.05.006 Abstract （101）      PDF（pc） （950KB）（32）       Knowledge map    Save Objective To observe the clinical efficacy of traditional Chinese medicine (TCM) combined with acupuncture in the treatment of tic disorders in children.Methods Totally 121 children with tic disorders treated in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2022 to June 2023 were selected and divided into observation group(n=56) and control group(n=65) according to different treatment methods. The control group was treated with TCM drugs combined with western drugs, and the observation group was treated with TCM drugs combined with acupuncture. The treatment period was 8 weeks. Observe the clinical efficacy, Yale global tic severity scale(YGTSS) score, and clinical global impression(CGI) score of the two groups.Results The total effective rate of the observation group was 82.1%(46/56), while the control group was 73.8%(48/65). There was no statistical difference between the two groups(P>0.05). After treatment, the observation group was superior to the control group concerning the effect on TCM syndrome(P<0.05). After treatment, the YGTSS score and CGI-SI scale score of the two groups significantly decreased; compared with those before treatment, the difference was statistically significant (P<0.05), but there was no statistically significant difference between the two groups (P>0.05). Subgroup analysis showed that: for different types of TCM syndrome differentiation, different types, and different severity of TD, the treatment was more effective than before treatment in both groups, but there was no statistical difference between the two groups(P>0.05).Conclusion The therapeutic effect of TCM drugs combined with acupuncture is equivalent to that of TCM drugs combined with Western medicine in the treatment of tic disorders. TCM drugs combined with acupuncture is helpful to improve the TCM syndrome of children and is worthy of clinical application. Related Articles | Metrics

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Professor Ma Rong's clinical approach to the diagnosis and treatment of Tourette disorder in children based on the concept of long-term management CHEN Haipeng, MA Rong Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (5): 398-400.   DOI: 10.3969/j.issn.1674-3865.2023.05.007 Abstract （68）      PDF（pc） （795KB）（143）       Knowledge map    Save Professor Ma Rong, based on the concept of long-term management, divides Tourette disorder into three stages: (1) Seizure stage: This stage is characterized by tic disorders, which belongs to the category of "liver wind" in traditional Chinese medicine. The syndrome differentiation is "internal movement of liver wind", and the treatment is mainly "stopping wind and movement". It is prohibited to reduce or stop medication, and it is advised to avoid participating in competitive social activities. (2) Prevention of recurrence stage: At this stage, children are mainly characterized by irritability and it belongs to the category of "liver fire" in traditional Chinese medicine. The syndrome differentiation is "vigorous liver fire", and the treatment is mainly "clearing and purging liver fire". Medication can be reduced appropriately, and it is not recommended to participate in competitive social activities. (3) Stable stage: At this stage, the main characteristic of the children is depression, and it belongs to the category of "liver depression" in traditional Chinese medicine. The syndrome differentiation is "liver depression and qi stagnation", and the treatment is mainly "soothing the liver and relieving depression". The medication can be reduced and stopped, and the child patients can participate in competitive social activities appropriately. Related Articles | Metrics

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The impact of Buqi Yijing Shengxue Chinese herbal medicines on histone-modifying enzymes in human erythroid cells CHEN Juexuan, XU Fangwei, LU Zhuoming Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (5): 401-406.   DOI: 10.3969/j.issn.1674-3865.2023.05.008 Abstract （111）      PDF（pc） （982KB）（53）       Knowledge map    Save Objective This study aims to investigate the impact of Buqi Yijing Shengxue Chinese herbal medicines, which are known for their generating blood by tonifying Qi and benefiting essence properties, on histone-modifying enzymes in the human erythroid K562 cell line.Methods K562 cells were induced with high and low concentrations of several groups of Chinese herbal medicines, including Buqi Yijing Shengxue drugs, Buqi Shengxue drugs and Yijing Shengxue drugs for blood generating, and sodium butyrate was used as a positive control. The mRNA levels of the γ-globin gene were assessed using real-time fluorescence quantitative PCR. Additionally, cellular HDAC1, HDAC2, and HAT enzyme activity levels were analyzed using an enzyme marker by colorimetric detection methods. The mRNA levels of HDAC1, HDAC2, and HAT genes were determined using the PCR method, while protein levels of these genes were determined via Western Blot.Results Treatment with Chinese herbal medicine and sodium butyrate significantly increased the expression levels of the γ-globin gene in high-dose Qi-tonifying and essence-benefiting group, high-dose Qi-tonifying group, and low-dose essence-benefiting group. Cellular HAT enzyme activity levels were notably higher in high and low-dose Qi-tonifying and essence-benefiting groups, as well as in high and low-dose essence-benefiting groups than in blank control group,while HDAC1 enzyme activity levels in the sodium butyrate group were markedly lower than those recorded in the blank control group. HAT mRNA levels were notably higher in high and low-dose Qi-tonifying and essence-benefiting groups, as well as in high-dose essence-benefiting group than in blank control group. Western Blot outcomes demonstrated that only the HAT protein levels in the high-dose Qi-tonifying and essence-benefiting group and high-dose essence-benefiting group were considerably elevated compared to those in the blank control group.Conclusion The molecular mechanism of Buqi Yijing Shengxue Chinese herbal medicines in the induction of γ-globin in gene expression in the treatment of pediatric β-thalassemia may be related to the regulation of the histone-modifying enzyme, which may be mediated by up-regulating the expression of histone acetyltransferase HAT to enhance histone modification in erythroid cells. Related Articles | Metrics

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Expert consensus on body constitution characteristics and nursing of children in traditional Chinese medicineBody Constitution WANG Qi, WANG Xuefeng, ZHAO Xia, LI Min Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 277-282.   DOI: 10.3969/j.issn.1674-3865.2023.04.001 Abstract （313）      PDF（pc） （857KB）（803）       Knowledge map    Save Expert consensus on body constitution characteristics and nursing of children in traditional Chinese medicineBody Constitution Research Committee of World Federation of Chinese Medicine Societies Related Articles | Metrics

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Study on the clinical efficacy of Changyu Dongzhi prescription in the treatment of children with tic disorder WANG Zhuang, WANG Yongji, WEI Lina, KONG Yibu, WANG Xiran Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 290-294.   DOI: 10.3969/j.issn.1674-3865.2023.04.003 Abstract （122）      PDF（pc） （853KB）（153）       Knowledge map    Save Objective To scientifically evaluate the clinical efficacy of Changyu Dongzhi prescription，which is based on a treatment method that simultaneously treats wind and fire,in the treatment of children with tic disorder （syndrome of liver wind hyperactivity）,and to provide evidence-based evidence for clinical application.Methods A total of 100 children with tic disorder （syndrome of liver wind hyperactivity） were chosen, who were treated at the Children's Diagnosis and Treatment Center of Changchun University of Traditional Chinese Medicine Affiliated Hospital from September 2021 to December 2022, and they were randomly divided into two groups using a random number table method, with 50 children in each group. The experimental group was treated with Changyu Dongzhi prescription with modification, which was taken orally，while the control group was treated with clonidine transdermal patches for application. The treatment lasted for 3 months. The clinical efficacy，average course of disease，and improvement of symptoms between the two groups were compared.Results The total effective rate of experimental group was 96.0%(48/50),higher than that of control group(84.0%,42/50),and there was statistical difference(P<0.05). In terms of YGTSS，traditional Chinese medicine syndrome score，disease course， and degree of symptom relief, the experimental group was better than the control group，with statistical differences （P<0.05）.Conclusion Changyu Dongzhi prescription can effectively alleviate the symptoms of tic disorder （syndrome of liver wind hyperactivity）and improve the therapeutic effect， which provides new ideas and plans for tic disorder,and is worthy of clinical promotion and application. Related Articles | Metrics

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Network pharmacological study on the mechanism of Acorus tatarinowii in the treatment of ADHD from phlegm theory HE Jingwei, LI Mengyao, LIANG Pengchen, ZHU Daqian, YU Jian Chinese Pediatrics of Integrated Traditional and Western Medicine    2023, 15 (4): 295-301.   DOI: 10.3969/j.issn.1674-3865.2023.04.004 Abstract （101）      PDF（pc） （1772KB）（160）       Knowledge map    Save Objective From the basic theory of traditional Chinese medicine based on "differentiated treatment from phlegm theory", the key target and mechanism of Acorus tatarinowii in the treatment of ADHD were discussed by means of network pharmacology.Methods The effective active components and potential targets of Acorus tatarinowii and disease targets of ADHD were screened by traditional Chinese medicine system pharmacology database, analysis platform (TCMSP database) and Genecards database. The common targets were screened on the R software platform; the protein-protein interaction (PPI) network was constructed; the "drug-active ingredient-target-disease" relationship was constructed; the GO and KEGG signal pathways were analyzed; pymol was used to visualize the docking results.Results Nine active components of Acorus tatarinowii and 99 intersection targets related to ADHD were screened out. Target proteins such as INS, AKT1, JUN, CASP3 and FOS were potential targets for intervention of ADHD by Acorus tatarinowii. The related targets involved multiple biological processes and molecular functions. The mechanism of Acorus tatarinowii in the treatment of ADHD was closely related to apoptosis-related pathways, inflammation-related pathways, lipid metabolic signal pathways, virus infection pathways and so on.Conclusion A variety of effective components of Acorus tatarinowii play a role through multiple signal pathways and different targets, reflecting the action mechanism and characteristics of multi-components, multi-targets, multi-links and multi-pathways of traditional Chinese medicine, which is helpful to explore the mechanism of Acorus tatarinowii in the treatment of ADHD. Related Articles | Metrics

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