Abstract:
Objective
To observe the therapeutic effect of traditional Chinese medicine decoction on children with purpura nephritis of Yin-deficiency and blood-heat type， and to explore its effect on peripheral blood Th17 cells in children with purpura nephritis.
Methods
The typical cases of Henoch-Schonlein purpura nephritis were collected and sorted out， and 100 cases of children were eventually identified as the research subjects. They were randomly divided into the observation group(50 cases) and the control group(50 cases). The observation group was treated with traditional Chinese medicine decoction orally， while the control group was treated with routine western medicine. After 4 weeks， the curative effect was evaluated and the changes of Th17 in serum were observed.
Results
The clinical total effective rate of the observation group was 82.0%(41/50), significantly higher than that of control group(58.0%,29/50), the difference being statistical significance(P<0.05). There was no statistical difference in the expression of peripheral Th17 cells between the two groups before treatment(P>0.05); however, after treatment it was lower, and it was even lower in observation group than in control group(P<0.05).
Conclusion
In the course of treatment of Henoch-Schonlein purpura nephritis， oral administration of traditional Chinese medicine decoction has better effect， which can reduce Th17 cells in children， and can regulate the immune function of children with Henoch-Schonlein purpura nephritis.

Key words: Henoch-Schonlein purpura nephritis, Chinese herbal decoction, Th17 cell, Child