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25 February 2012, Volume 4 Issue 1 Previous Issue    Next Issue

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Experimental study on the prevention and treatment effect of Guben Zhixiao prescription on bronchial asthma XIE Xiaoshu,ZHANG Shiqing. 2012, 4 (1):  16-18.  doi: 10.3969/j.issn.1674-3865.2012.01.006 Abstract ( 308 )   PDF (357KB) ( 85 )   Save Objective:To observe the effect of Guben Zhixiao prescription in the prevention of asthma in young rats. Methods:Take 100 young rats,but select only 60,who were divided into 5 groups randomly;the blank group and the model group were given physiological saline stomach irrigation for 28 days,the other 3 groups with 28 days of medicine irrigation.Except the blank group,asthma model was made in all the other groups(by egg albumin all(OVA) intraperitoneal injection sensitization and  atomization inhalation stimulation).Observe the effect of irrigation in rat stomach on day 14 on the incubation period;when rats had contact with 1% OVA smog for the first time observe if there was symptoms of asthma and record the level,compare the asthma incidence(level 3) among the groups. Results:(1)After 14 days of irrigation and compared with the model group,Guben Zhixiao prescription in large or small dose had longer incubation period,which had significant difference(P<0.05).(2)Compared with the model group at the first time of contact between rat and 1% OVA aerosol,Guben Zhixiao prescription apparently reduced asthma level,with significant difference(P<0.05);(3)On 4 and 7 days of stimulation,and compared with model group in Guben Zhixiao prescription in large or small dose group,level 3 asthma rates had a significant decrease,with significant difference(P<0.05). Conclusions:Guben Zhixiao prescription can extend the incubation period in rats,reduce asthma rates,reduce asthma degree,and has good prevention and cure effect on the young rats asthma. Related Articles | Metrics

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The relationship between serum asymmetric dimethylarginine and premature respiratory distress syndrome HUANG Huijuan,CHEN Weiqi,ZHENG Kaijun,et al. 2012, 4 (1):  19-22.  doi: 10.3969/j.issn.1674-3865.2012.01.007 Abstract ( 379 )   PDF (459KB) ( 82 )   Save Objective:To investigate the relationship between ADMA and NRDS and whether cord blood concentration of ADMA is a reliable biochemical marker to predict respiratory distress syndrome in preterm infants. Methods:Eighteen preterm infants with NRDS were included in experimental group and seventeen preterm infants whose gestation age was less then 35 weeks and birth weight was less than 2 500 g were in control group.Experimental group was divided into stage one group and stage two group.Draw 2 mL umbilical cord blood,and then draw 2 mL of radial artery blood respectively at 7 days and 14 days after birth.All the procedures were carried out strictly according to the supplied structure manuals in the ELISA kits. Results:(1)There was no linear correlation between the level of cord plasma concentrations of ADMA and birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy.(2)In stage two group the level of cord plasma concentration of ADMA was significantly higher than that of stage one and the control group(P<0.05).The levels at 7 days and 14 days were not significantly different between experimental group and control group.(3)The level of cord plasma concentration of ADMA in stage two group was significantly related to length of mechanical ventilation(r=0.532,P<0.05) and the length of oxygen(r=0.663,P<0.05). Conclusions:The level of cord plasma concentration of ADMA is negatively correlated with birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy.ADMA may be able to predict the occurrence of stage two NRDS.The higher the level of cord plasma concentrations of ADMA,the longer the time of mechanical ventilation and oxygen inhalation. Related Articles | Metrics

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Therapeutic effect of anklefoot orthoses on the children with spastic cerebral palsy LV Zhihai，ZHANG Zhen，LI Yingying，et al. 2012, 4 (1):  25-27.  doi: 10.3969/j.issn.1674-3865.2012.01.009 Abstract ( 330 )   PDF (403KB) ( 114 )   Save Objective:To observe the therapeutic effect of anklefoot orthoses(AFO) on the children with spastic cerebral palsy(CP). Methods:The children with spastic CP were divided into observation group(n=20) and control group(n=20).Both the two groups were trained with Traditional rehabilitation training，and the observation group was added with AFO to treat static and dynamic tiptoe.After one course of treatment(3 months) the crus triceps muscular tone was evaluated via the modified Ashworth Rating Scale(MAS),and the gross motor function via Gross Motor Function Measurement(GMFM). Results:The crus triceps muscular tone in the observation group was much lower than that in the control group(P<0.05),and the scores of GMFM in the observation group were much higher than those in the control group(P<0.01) after treatment. Conclusions:AFO can decrease the crus triceps muscular tone of the children with spastic CP and improve the gross motor function. Related Articles | Metrics

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The systematic review on medicine for tonifying kidney and promoting blood flow in the treatment of primary nephrotic syndrome in children QIU Caixia，ZHENG Jian，HUANG Suping. 2012, 4 (1):  31-37.  doi: 10.3969/j.issn.1674-3865.2012.01.012 Abstract ( 337 )   PDF (1103KB) ( 100 )   Save Objective:To assess the curative effect and the security of the medicine for tonifying kidney and promoting blood flow in the treatment of primary nephrotic syndrome in children. Methods:Through retrieval Cochrane,MEDLINE,CNKI,VIP,CBM and Fulltext data base of Chinese Drs and Lics were searched,and the search time was from Jan 2000 to July 2011.RCTs related medicines for tonifying kidney and promoting blood flow of in primary nephrotic syndrome in children were collected.The literature quality was evaluated by Jadad Score and the data analysis was made by RevMan 5.0 software.Thirteen indexes were selected namely,TC,TG,TXB2,6ketoPGF1a,CD3,CD4,CD8,CD4/CD8,ALB,24 h urine protein,compound F,relapse rate and clinical manifestation. Results:Thirteen studies were included in the analysis, totally 725 patients.Jadad Scores were all 3 points.Meta analysis showed:except for compound F,the other 12 indexes showed obvious difference from the control group(P<0.05).To some degree,the curative effect of Western medicine combined with the medicine for tonifying kidney and promoting blood flow was better than solitary western medicine,and there was fewer adverse reactions,so it`s safe and reliable. Conclusions:Present evidence shows that the medicine drug for tonifying kidney and promoting blood flow has effect on curing primary nephrotic syndrome in children.Limited by quantity and quality of the literature searched,its curative effect and safety need more highquailty RCT experiments. Related Articles | Metrics