ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 560-562.doi: 10.3969/j.issn.1674-3865.2015.06.009

• 临床研究 • 上一篇    下一篇

哮喘患儿血清炎性介质变化及临床意义

张宏,王丙增,张旭亚,况琦,孟凡威,付晓梅   

  1. 475001 河南 开封,河南大学第一附属医院儿科
  • 出版日期:2015-12-25 发布日期:2018-11-19
  • 通讯作者: 张宏，E-mail：zhanghong20048088@126.com
  • 作者简介:张宏(1978-),男,医学硕士,主治医师。研究方向：器官纤维化的临床研究

Changes of serum inflammatory mediators in children with asthma and its clinical significance

ZHANG Hong，WANG Bingzeng，ZHANG Xuya，KUANG Qi, MENG Fanwei,FU Xiaomei   

  1. The First Affiliated Hospital of Henan University，Kaifeng 475001，China.
  • Online:2015-12-25 Published:2018-11-19

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摘要：
目的: 测定哮喘儿童血清生长因子β1(TGFβ1)、Ⅰ型纤溶酶原激活物抑制因子(PAI-1)、基质金属蛋白酶-９(MMP-9)的表达变化,探讨TGF-β1、PAI-1、MMP-9在儿童支气管哮喘呼吸道重塑的作用机制。
方法:选取符合支气管哮喘诊断的患儿40例,给予布地奈德雾化吸入治疗,采集患儿血清检测治疗前后TGF-β1、PAI-1、MMP-9水平变化,同时观测肺功能的变化,并与对照组(健康儿童)比较。
结果:经测定哮喘患儿血清样本中的TGF-β1、PAI-1、MMP9含量均明显增高,与对照组比较,差异有统计学意义(P＜0.05);同时测的FEV1、PEF的百分比均降低；观察组给予布地奈德雾化吸入治疗后,哮喘患儿血清样本中的GF-β1、PAI-1、MMP-9含量逐渐下降,与治疗前比较,差异有统计学意义(P＜0.05)；同时测的FEV1、PEF的百分比与治疗前比较显著好转,差异有统计学意义(P＜0.01)。
结论:TGF-β1、PAI-1、MMP-9水平变化与儿童支气管哮喘有重要的相关性；布地奈德雾化吸入治疗能明显改善患儿的呼吸情况,其机制可能是通过降低TGF-β1、PAI-1、MMP-9的水平而抑制气道重塑以及气道炎症,达到治疗哮喘的目的。

关键词: 哮喘, TGF-β1, PAI-1, MMP-9, 气道重塑, 儿童

Abstract:
Objective：To determine the expression of TGF-β1, PAI-1 and MMP-9,and to study their mechanism of action in bronchial asthma airway remodeling in children.
Methods：Forty patients with bronchial asthma in children were given budesonide atomization inhalation treatment and serum were collected and detected before and after treatment for TGF-β1, PAI-1 and MMP-9 levels. At the same time we observed changes in lung function, and compared with the control group (healthy children).
Results：In the serum samples of children with asthma the TGF-β1, PAI-1 and MMP-9 content increased significantly (compared with the control group), and the differences were statistically significant (P＜0.05); at the same time, percentage of FEV1 and PEF decreased; after budesonide inhalation treatment, TGF-β1, PAI-1 and MMP-9 content decreased, and compared with before treatment, there were significant statistical differences (P＜0.05); the percentage of FEV1 and PEF was significantly improved compared with those before treatment, the difference being statistically significant (P＜0.01).
Conclusion：PAI-1, MMP-9 and TGF-β1 changes in children are closely related to bronchial asthma; budesonide inhalation therapy can significantly improve the respiratory condition of the patients, and the possible mechanism may be by reducing the TGF-β1, PAI-1 and MMP-9 level to ihibit airway remodeling and airway inflammation, and achieve the purpose of treating asthma.

Key words: Asthma, TGF-β1, PAI-1/MMP-9, Airway remodeling, Children