ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 612-615.doi: 10.3969/j.issn.1674-3865.2016.06.021

• 临床研究 • 上一篇    下一篇

血浆前白蛋白和白细胞计数对川崎病患儿冠状动脉病变预测的意义

梁芳,李超雄,张翠媛   

  1. 529000 广东 江门，江门市中心医院儿科
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 通讯作者: 梁芳，E-mail：liangfang021@163.com
  • 作者简介:梁芳(1979-)，女，医学硕士，主治医师。研究方向：小儿内科疾病的诊治

Significance of plasma pre albumin combined with white blood cell count in predicting of coronary artery disease in patients with Kawasaki disease

LIANG Fang,LI Chaoxiong,ZHANG Cuiyuan   

  1. Jiangmen Central Hospital，Jiangmen 529000，China
  • Online:2016-12-25 Published:2018-11-19

PDF (PC)

135

摘要： 目的：探讨血浆前白蛋白(PA)和白细胞计数(TLC)对川崎病患儿冠状动脉病变预测的意义。
方法：分析2013年1月至2016年1月江门市中心医院院收治的川崎病患儿83例，分析其病例资料，包括血浆中PA水平、TLC和冠状动脉超声检查结果等。采用t检验、χ2检验以及ROC曲线下面积(AUC)与截断值计算等统计方法，对PA和TLC与冠状动脉病变进行相关性分析。
结果：在川崎病患儿的急性期，血浆PA水平为(72.39±46.81)mg/L，较正常参考值显著下降，TLC计数为(16.47±6.49)×109/L，较正常参考值显著升高，差异均有统计学意义(P<0.05)。PA的AUC为0.699，具有诊断意义，PA水平选择界限值为48.5 mg/L时，预测冠状动脉扩张的敏感度为73.3%，特异度为64.5%。
结论：PA和TLC在川崎病急性期有显著变化，联合分析PA和TLC变化，对于预测冠状动脉病变可能具有重要意义，但不能据此判断冠状动脉病变类型与程度。

关键词: 川崎病, 冠状动脉病变, 前白蛋白, ROC曲线, 儿童

Abstract: Objective:To analyze the changes of plasma pre albumin(prealbumin, PA) and white blood cell count(total leukocyte count, TLC) in patients with Kawasaki's disease in order to investigate the significance of combined analysis of PA and TLC changes in predicting coronary artery disease.
Methods:A retrospective analysis of 83 cases of children with Kawasaki's disease in our hospital from January 2013 to January 2016 were carried out. Analyze the case data，which included the plasma level of TLC, PA and the Results: of ultrasound examination of the coronary artery, etc. Use t test, Chi-square test and area under the ROC curve and the calculation of the cut-off value of statistical Methods to analyze the correlation between PA, TLC and the coronary artery disease.
Results:In the acute phase of patients with Kawasaki, the plasma Mg level was (72.39±46.81)×109/L PA, which was significantly decreased compared with the normal reference value, and the TLC count was (16.47±6.49)×109/L, which was significantly higher than the normal reference value, and the difference was statistically significant(P＜0.05). The ROC curve was used to calculate the area of PA, and the AUC was 0.699, which was of diagnostic value. When the threshold value of PA level was 48.5 mg/L, the sensitivity and specificity of predicting coronary artery dilatation were 73.3% and 64.5%, respectively.
Conclusion：PA and TLC have significant changes in the acute stage of Kawasaki's disease. Combined analysis of changes in PA and TLC may have important implications for the prediction of coronary artery disease, but can not be used to judge the type and extent of coronary artery disease.

Key words: Kawasaki disease, Coronary artery disease, Pre albumin, ROC curve, Child