ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 106-109.doi: 10.3969/j.issn.1674-3865.2018.02.005

• 临床研究 • 上一篇    下一篇

降钙素原检测在支气管肺炎患儿治疗中的临床价值及与白细胞计数、C反应蛋白的相关性

朱健，张志巧，王伟，陆海迪，郁宇宏，毛惠清，吴旭东，贺从真，梅士兰   

  1. 215400 南京，南京中医药大学附属太仓市中医医院儿科
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 通讯作者: 朱健，E-mail：965971472@qq.com
  • 作者简介:朱健（1963-），男，副主任医师。研究方向：儿科呼吸系统及其他系统疾病的临床和教学研究
  • 基金资助:
    江苏省太仓市科技支撑计划-社会发展课题项目（32005）

Clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein

ZHU Jian，ZHANG Zhiqiao，WANG Wei，LU Haidi，YU Yuhong，MAO Huiqing，WU Xudong，HE Congzhen，MEI Shilan   

  1.  Taicang TCM Hospital Affiliated to Nanjing University of Traditional Chinese Medicine，Nanjing 215400，China
  • Online:2018-04-25 Published:2018-11-19

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摘要：
目的
通过检测患儿血清降钙素原以指导抗生素的合理使用，探讨降钙素原在治疗支气管肺炎患儿疾病中的临床价值及其与白细胞计数、C反应蛋白的相关性。
方法
选择2014年7月至2016年12月南京中医药大学附属太仓市中医医院儿科收治住院的支气管肺炎患儿180 例，随机分为对照组和观察组各90例。对照组为常规治疗，观察组为在降钙素原水平的指导下使用抗生素的治疗。观察两组治疗前后体温、白细胞计数、C反应蛋白、降钙素原、退热时间、住院时间、抗生素使用时间及其使用率。分析降钙素原与白细胞计数、C反应蛋白的相关性。
结果
两组患儿治疗后体温、白细胞计数、C反应蛋白以及降钙素原各项指标均低于治疗前，差异有统计学意义（P<0.05）；但治疗前后各指标两组比较差异无统计学意义（P>0.05）。两组退热时间和住院时间比较差异无统计学意义（P>0.05）。观察组抗生素使用时间显著短于对照组，抗生素使用率也显著低于对照组，差异有统计学意义（P<0.05）。降钙素原与白细胞计数、C反应蛋白水平均成正相关关系，差异有统计学意义（P<0.05）。
结论
通过检测血清降钙素原可更有效的指导临床抗生素的使用，在治疗儿童支气管肺炎疾病中具有重要的临床价值，可有效避免临床的滥用抗生素现象。

关键词: 支气管肺炎, 降钙素原, 抗生素, 儿童

Abstract:
objective
To investigate the clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein by detecting serum procalcitonin in children to guide the rational use of antibiotics.
Methods
A total of 180 children with bronchial pneumonia who were admitted from July 2014 to December 2016 to the Affiliated Hospital of Taicang Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine were selected and randomly divided into control group and observation group with 90 cases in each. The control group was treated routinely, and the observation group was treated with antibiotics based on procalcitonin levels. The body temperature, white blood cell count, C-reactive protein, procalcitonin, antipyretic time, hospital stay, antibiotic use time, and its use rate before and after treatment were observed. The correlation between procalcitonin and leukocyte counts and C-reactive protein was analyzed.
Results
There was statistical difference in body temperature, WBC count, C-reactive protein and procalcitonin in the two groups, which were all lower after treatment(P<0.05). There was no significant difference in the control of body temperature, white blood cells, C-reactive protein and procalcitonin between the treatment group and the control group(P>0.05).There was no significant difference in antipyretic time or hospital stay between the two groups(P>0.05).Antibiotic use time in the observation group was significantly shorter than that in the control group, and the antibiotic use rate was also significantly lower than that in the control group. The difference was statistically significant(P<0.05).Procalcitonin was positively correlated with leukocyte count and C-reactive protein levels, and the difference was statistically significant(P<0.05).
Conclusion
The detection of serum procalcitonin can more effectively guide the use of clinical antibiotics. It has important clinical value in the treatment of children with bronchopneumonia and can effectively avoid clinical abuse of antibiotics.

Key words: Bronchial pneumonia, Procalcitonin, Antibiotics, Children