ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (1): 86-88.doi: 10.3969/j.issn.1674-3865.2020.01.024

• 临床研究 • 上一篇    下一篇

丙种球蛋白辅助治疗原发免疫性血小板减少症患儿的效果分析

田莹，程永昌，范晓娜   

  1. 745000 甘肃 庆阳，庆阳市中医院血液病科（田莹，范晓娜），普外科（程永昌）
  • 出版日期:2020-02-25 发布日期:2021-05-17
  • 通讯作者: 田莹，E-mail：tianyinghnr@163.com
  • 作者简介:田莹（1981-），女，主治医师。研究方向：临床血液病的诊治

Effect analysis of gamma globulin in adjuvant therapy for children with primary immune thrombocytopenia

  • Online:2020-02-25 Published:2021-05-17

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摘要： 目的 研究丙种球蛋白辅助治疗小儿原发免疫性血小板减少症的效果。 方法 选取2017年3月至2018年4月于我院血液内科治疗的原发免疫性血小板减少症患儿72例，随机分为对照组和观察组各36例。对照组行常规激素治疗，观察组在此基础上行丙种球蛋白治疗。比较两组患儿的临床治疗效果、血小板恢复时间、出血停止时间、不良反应发生率及复发率情况。 结果 观察组临床效果明显优于对照组，差异有统计学意义（P<0.05）。治疗后观察组患儿血小板恢复时间及出血停止时间均明显短于对照组，差异具有统计学意义（P<0.05）。观察组患儿不良反应发生率为8.33%（3/36）,低于对照组27.78%(10/36)，差异具有统计学意义（P<0.05）。随访5个月，观察组复发率为2.78%（1/36），对照组16.67%（6/36），两组比较差异无统计学意义（P>0.05）。 结论 丙种球蛋白辅助治疗小儿原发免疫性血小板减少症能明显缩短患儿血小板恢复时间和出血停止时间，临床效果好，不良反应发生率低。

关键词: 原发免疫性血小板减少症, 丙种球蛋白, 血小板计数, 儿童

Abstract: Objective To study the effect of gamma globulin in adjuvant treatment of primary immune thrombocytopenia in children Methods Totally 72 children with primary immune thrombocytopenia treated in the department of hematology of our hospital from March 2017 to April 2018 were randomly divided into control group and observation group,36 cases each The control group received conventional hormone therapy,while the observation group received gamma globulin therapy on this basis The clinical treatment effect,platelet recovery time,bleeding cessation time,incidence of adverse reactions and recurrence rate of the two groups were compared Results The clinical effect of the observation group was significantly better than that of the control group,the difference being statistically significant (P<0.05) After treatment,the platelet recovery time and bleeding cessation time in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05) The incidence of adverse reactions in the observation group was 8.33%(3/36),lower than that in the control group(27.78%，10/36),and the difference was statistically significant(P<0.05) The 5month followup showed that the recurrence rate in the observation group was 2.78%(1/36),lower than that in the control group (16.67%，6/36),with no statistically significant difference(P>0.05) Conclusion Gamma globulin in adjuvant therapy for primary immune thrombocytopenia in children can significantly shorten the time of platelet recovery and bleeding cessation in children,with good clinical effect and low incidence of adverse reactions

Key words: Primary immune thrombocytopenia, Gamma globulin, Platelet count, Children