ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (3): 209-211.doi: 10.3969/j.issn.1674-3865.2020.03.007

• 孤独症治疗专栏 • 上一篇    下一篇

重复经颅磁刺激治疗2～6岁孤独症儿童疗效分析

董宠凯，张继华，高丙南，葛潇，江果，赵莹莹   

  1. 450000 郑州，河南省省立医院康复科
  • 出版日期:2020-06-25 发布日期:2021-05-17
  • 通讯作者: 张继华，E-mail：22440274@qq.com
  • 作者简介:董宠凯（1985-），男，医学硕士，主治医师。研究方向：小儿神经及精神行为疾病的康复

Efficacy of repetitive transcranial magnetic stimulation(TMS) in the treatment of children with autism spectrum disorders aged 2-6 years

  • Online:2020-06-25 Published:2021-05-17

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摘要： 目的 探讨重复经颅磁刺激治疗（rTMS）联合康复训练包括行为分析治疗、社交训练、言语治疗、感觉统合训练对孤独症谱系障碍（ASD）儿童刻板行为的疗效分析。 方法 选取2017年9月至2019年9月在河南省省立医院康复科住院的ASD儿童60例，随机分为对照组和观察组各30例。两组儿童均接受应用行为分析疗法、言语治疗和感觉统合训练。观察组在对照组基础上加用rTMS（且rTMS在康复训练之前）。疗程12周，治疗前后分别用儿童孤独症评定量表（CARS）和孤独症行为检查量表（ABC）进行评估。比较两组核心症状总改善率。 结果 治疗12周后，两组ABC评分及CARS评分均较治疗前明显减少，差异有统计学意义(P<0.05)，且观察组ABC评分及CARS评分均明显低于对照组，差异有统计学意义(P<0.05)。观察组核心症状总改善率为100%（30/30），明显高于对照组86.7%（26/30），差异有统计学意义（P<0.05)。 结论 rTMS联合康复训练、常规康复训练对ASD儿童核心症状均有一定的促进作用；rTMS联合康复训练的疗效明显优于常规康复训练。

关键词: 孤独症谱系障碍, 重复经颅磁刺激, 核心症状, 儿童

Abstract: Objective To explore the repetitive transcranial magnetic stimulation(rTMS) combined rehabilitation training，including behaviour analysis therapy，social training，speech therapy，and sensory integration training，on the stereotyped behavior of children with autism spectrum disorder(ASD). Methods Sixty ASD children，who were hospitalized and treated in Henan Provincial Hospital from Sep. 2017 to Sep. 2019, were randomly divided into rTMS group and control group， with 30 cases in each group. The two groups of children received the behavior analysis therapy，speech therapy and sensory integration training. The rTMS group was given additional rTMS therapy(rTMS was performed before rehabilitation training). The course of treatment was 12 weeks. Before and after treatment，the childhood autism rating scale(CARS) and autism behavior check scale(ABC) were used to evaluate. The total improvement rate of core symptoms was compared between the two groups. Results After 12 weeks of treatment，the CARS and ABC scores of the two groups were significantly lower than those before treatment(P<0.05). The CARS and ABC scores in the rTMS group were significantly lower than those in the control group（P<0.05）， and the overall improvement rate of core symptoms in rTMS group(100%,30/30) was significantly higher than that in the control group (86.7%,26/30)(P<0.05). Conclusion The rTMS combined with rehabilitation training and conventional rehabilitation training has certain promoting effects on core symptoms of children with ASD. The efficacy of rTMS combined rehabilitation training is significantly better than conventional rehabilitation training.

Key words: Autism spectrum disorder, Repetitive transcranial magnetic stimulation, Core symptoms, Children