ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (4): 328-330.doi: 10.3969/j.issn.1674-3865.2020.04.014

• 临床研究 • 上一篇    下一篇

小儿暴发性心肌炎氨基末端脑利钠肽前体测定的临床意义

孙胜涛，李银凤，马云霞，高芹玲，张庆彪，刘文龙，刘海滨，潘筱   

  1. 276002 山东 临沂，临沂市人民医院小儿心脏科
  • 出版日期:2020-08-25 发布日期:2021-05-17
  • 通讯作者: 李银凤，E-mail：yinfengli@163.com
  • 作者简介:孙胜涛（1969-），男，医学硕士，副主任医师。研究方向：小儿心血管系统疾病的诊治

Clinical significance of the determination of N-terminal pro brain natriuretic peptide in children with fulminant myocarditis

  • Online:2020-08-25 Published:2021-05-17

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摘要： 目的 探讨小儿暴发性心肌炎氨基末端脑利钠肽前体（NT-proBNP）测定的临床意义，以指导临床小儿暴发性心肌炎的诊断和治疗。
方法 选择我院于2008～2018年10年间小儿心脏科确诊的14例暴发性心肌炎患儿，同期选择轻型心肌炎患儿14例和健康体检儿童14例作为对照组。采用化学发光法检测NT-proBNP数值。结果 暴发性心肌炎患儿急性期NT-proBNP与暴发性心肌炎恢复期、轻型心肌炎组、对照组比较明显升高,差异有统计学意义（P<0.05）。轻型心肌炎组NT-proBNP与对照组比较也明显升高，差异有统计学意义（P<0.05），
结论 NT-proBNP可以作为暴发性心肌炎诊断和判断预后的重要的指标。

关键词: 暴发性心肌炎, 氨基末端脑利钠肽前体, 儿童

Abstract: Objective To investigate clinical value of N-terminal pro brain natriuretic peptide(NT-proBNP) detection in children with fulminant myocarditis(FM), in order to guide the diagnosis and treatment of children with FM.
Methods A total of 14 children with FM and 14 children with mild myocarditis treated in our hospital from 2008 to 2018 were selected. Fourteen healthy children were selected as healthy control group. The level of NT-proBNP was tested by automatic biochemical analyzer.
Results The level of NT-proBNP in FM children at acute stage was significantly higher than that in FM children at recovery stage, the children with mild mycarditis and healthy control group（P＜0.05）. The level of NT-proBNP in mild myocarditis was significantly higher than that in healthy control group（P＜0.05）.
Conclusion The level of NT-proBNP may be used as an important marker in the diagnosis and the judgement of prognosis of fulminant myocarditis.

Key words: Fulminant myocarditis, N-terminal pro brain natriuretic peptide, Children